Results 41 to 50 of about 484,814 (261)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Consistency in international law

, 2023
Unlike domestic law, where rule-making is the job of legislative houses, rule-making in international law is decentralised. No central authority or unified government creates international legal rules. Instead, its subjects build international law by signing treaties, practising customs, and recognising general principles.
openaire   +1 more source

Consistency of international sentencing: ICTY and ICTR case study [PDF]

European Journal of Criminology, 2012
The International Criminal Tribunal for the Former Yugoslavia and the International Criminal Tribunal for Rwanda are the first, post Cold War international criminal tribunals convicting perpetrators of genocide, crimes against humanity and war crimes. Their sentencing practice has been largely criticized as inconsistent.
Hola, B., Bijleveld, C., Smeulers, A.L.
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Psychometric properties of the Adolescent Motor Competence Questionnaire for Norwegian adolescents

Frontiers in Psychology
The objective of this study was to examine the psychometric properties of the Adolescent Motor Competence Questionnaire (AMCQ) for Norwegian adolescents.
Håvard Lorås, Monika Haga, Ruben Vist Hagen, Øyvind Bjerke, Amanda Timler, Ole Johan Sando   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Invariance and item bias of the Mental Health Continuum Short-Form for South African university first-year students

African Journal of Psychological Assessment
Over the last decade, higher education institutions (HEIs) have become increasingly interested in student well-being. However, since the student population is very diverse in South Africa, questionnaires measuring the well-being of students must be ...
Karina Mostert, Leon de Beer, Ronalda de Beer   +2 more
doaj   +1 more source

Evaluation of the Georgia Elementary School Climate Survey for elementary school children [PDF]

International Journal of Emotional Education, 2021
School climate is a vital aspect of school life that influences students’ emotional well- being, social relations and academic achievement. Therefore, educators need to monitor school climate to nurture good interpersonal relations and students’ positive
Victor Martinelli, Milosh Raykov
doaj  

Annual Baseline King-Devick Oculomotor Function Testing Is Needed Due to Scores Varying by Age

Sports, 2021
Objective: To document baseline King-Devick (K-D) oculomotor function scores for male and female participants aged between 4 and 20 years old. Methods: Utilising a cross section of schools, rugby clubs and gymnastic clubs, 1936 participants (1300 male ...
Dearbhla Gallagher, Doug King, Patria Hume, Trevor Clark, Alan Pearce, Conor Gissane   +5 more
doaj   +1 more source