Results 31 to 40 of about 2,073,166 (266)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm +11 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Binus Business Review, 2010 PT Inti Dufree Promosindo is a subsidiary of PT Sona Topas Tourism Industry, Tbk. The company is one of the biggest retail companies that sell local and imported products. This business is also called duty free shop. PT.
Elisia Elisia, Stefanus Ariyanto
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Evaluation of Priority Objectives and the Functioning of Internal Control in Companies of Šumadija and Raška Districts [PDF]
Economic Horizons, 2019 Without the existence of a internal control system in today’s conditions of business operations, managing a company would be unthinkable. The presence of control allows the performance of business activities according to a plan through the preventive ...
Biljana Jovkovic
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Investigating the Impact of Disclosing Internal Control Weaknesses on Labor Investment Efficiency [PDF]
بررسیهای حسابداری و حسابرسیObjective This study is to examine the relationship between the disclosure of internal control weaknesses and the efficiency of human resources investment in companies listed on the Tehran Stock Exchange. Since investment in human resources is recognized
Salman Beik Boshroueyh +2 more
doaj +1 more source
Internal Control Weakness and Managerial Myopia: Evidence from SOX Section 404 Disclosures [PDF]
ACRN Journal of Finance and Risk Perspectives, 2019 Problem/ Relevance: Managerial myopia is an important issue of interests to academics, practitioners, and regulators as managers have been condemned for their obsession with short-term earnings and myopic investment decisions that sacrifice firms’ long ...
Amy E. Ji
doaj +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Internal control of organization:content, objects, points of implementation
Путеводитель предпринимателя, 2020 The article concerns topical issues of internal control organization and its implementation. The basic elements of the accounting policies, regulating the order of the control procedures, are marked.
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