Results 41 to 50 of about 4,992,865 (302)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Controversial Aspects of the Internal Control Concept
Учёт. Анализ. Аудит, 2018 The logic of the paper is based on defining the key aspects of internal control notion as a phenomenon in modern management process. The article considers the issues of applying Article 19 “Internal control” of the Federal Act 402 taking into ...
A. V. Bоdуako
doaj +1 more source
The Effectiveness of Internal Control in Village Fund System
AFRE (Accounting and Financial Review), 2022 The Financial and Development Supervisory Agency forms Siskeudes to facilitate the village governance system and the village funds management. Internal control is one of the essential components to mitigate the risk of misuse of village funds. This study
Kezya Audela, Ika Kristianti
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Simulation of a model-based optimal controller for heating systems under realistic hypothesis [PDF]
, 2005 An optimal controller for auxiliary heating of passive solar buildings and commercial buildings with high internal gains is tested in simulation. Some of the most restrictive simplifications that were used in previous studies of that controller (Kummert ...
Andre, Philippe, Kummert, Michael
core
, 2012 In this paper we deal with the local null controllability of the N-dimensional Navier-Stokes system with internal controls having one vanishing component.
E. Fernández-Cara +7 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
FEATURES OF INTERNAL/MANAGERIAL CONTROL IN PUBLIC ORGANIZATIONS [PDF]
Journal of Defense Resources Management, 2014 Control aims at the protection of patrimony, the quality of information, and the increase of performance and application of guidelines coming from the management of the public organization.
Gheorghe MINCULETE +1 more
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