Results 81 to 90 of about 2,194,012 (303)

Reservoir theory for studying the geochemical evolution of soils [PDF]

, 2010
[1] Linking mineral weathering rates measured in the laboratory to those measured at the landscape scale is problematic. In laboratory studies, collections of minerals are exposed to the same weathering environment over a fixed amount of time. In natural
Almond, Amundson, Anderson, Anderson, Anderson, Baldwin, Birkeland, Blum, Brantley, Brantley, Brown, Burke, Butler, Carson, Chadwick, Dietrich, Dietrich, Dixon, Eriksson, Fernandes, Ferrier, Furbish, Gabet, Gabet, Gabet, Heimsath, Heimsath, Hren, Jenny, Johnson, Johnson, Kaste, Kirkby, Kyungsoo Yoo, Lebedeva, Montgomery, Mudd, Mudd, Mudd, Nikiforoff, Porder, Porder, Prosser, Riebe, Riebe, Rodhe, Roering, Roering, Simon Marius Mudd, Small, Trumbore, Waldbauer, Walker, West, White, Yoo, Yoo, Yoo, Yoo   +58 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A Auditoria e os Sistemas de Controles Internos no Brasil: Antecedentes e Evolução

Revista de Economia Mackenzie, 2007
The Independent or External Auditing is the branch of Accounting which copes with the examination of financial accounts to check their accuracy. The final objective is the issuing of an Auditor’s Report, which is a written attestation as to the ...
Sergio Arnor Vieira
doaj  

Effect of internal controls on credit risk among listed Spanish banks

Intangible Capital, 2016
Purpose: The paper examines the effectiveness of internal control systems, explores the exposure of Spanish banks to the dangers of default as a result of internal control systems and establishes a relationship between internal controls and credit risk ...
Ellis Kofi Akwaa-Sekyi, Jordi Moreno Gené   +1 more
doaj   +1 more source

Exact controllability to the trajectories for parabolic PDEs with nonlocal nonlinearities [PDF]

, 2019
This paper deals with the analysis of the internal control of a parabolic PDE with nonlinear diffusion, nonlocal in space. In our main result, we prove the local exact controllability to the trajectories with distributed controls, locally supported in ...
Fernández Cara, Enrique, Limaco Ferrel, Juan, Nina Huaman, Dany, Núñez Chávez, Miguel R.   +3 more
core  

Management control in the transfer pricing tax compliant multinational enterprise [PDF]

, 2008
This paper studies the impact of transfer pricing tax compliance on management control system (MCS) design and use within one multinational enterprise (MNE) which employed the same transfer prices for tax compliance and internal management purposes.
Cools, M., Emmanuel, C., Jorissen, A.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Sensitive Single-Stage PCR Using Custom-Synthesized Internal Controls

BioTechniques, 2000
A new approach for an internally controlled PCR was developed using a customsynthesized oligonucleotide as the internal control. Three different PCR setups demonstrated the usefulness of this approach: (i) the addition of the respective internal control ...
K. Zimmermann, M. Rieger, P. Groß, P.L. Turecek, H.P. Schwarz   +4 more
doaj   +1 more source

Effect of intrauterine morphine sulfate exposure on cerebellar histomorphological changes in neonatal mice [PDF]

, 2011
Neurotoxic effects of morphine sulfate in adult cerebellar cortex and neonatal cerebral cortex have been studied in animal models. This study was done to determine the neurotoxic effects of prenatal morphine exposure on the histo morphological changes of
Ghafari, S., Golalipour, M.J., Roshandel, D.   +2 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source