Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs +7 more
wiley +1 more source
Triggers of internal displacement in Guatemala
More than 20 years since the end of the civil war, Guatemala is once again experiencing an upsurge in internal displacement. The causes are multiple, and demand attention.
Sindy Hernández Bonilla
doaj
CIVIL CONFLICT AND FORCED MIGRATION: THE MICRO DETERMINANTES AND THE WELFARE LOSSES OF DISPLACEMENT IN COLOMBIA [PDF]
During the last decade, forced internal displacement in Colombia has been a growing phenomenon closely linked to the escalation of the internal armed conflict - particularly in rural areas.
Ana Maria Ibáñez +1 more
core
The human cost of disaster displacement in Bangladesh: A life-year approach to understanding impacts
Bangladesh is among the countries most affected by disaster displacement worldwide. Between 2008 and 2025, disasters, primarily cyclones, floods and storm surges, triggered more than 21 million movements.
core +1 more source
Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova +9 more
wiley +1 more source
Many countries face the problem of refugees and internal displacement. Internal displacement is not new to Kenya and is a recurring problem that impacts displaced children’s education.
Caroline Adhola, Anne Ajulu-Okungu
doaj +1 more source
A life-year approach for measuring the human cost of disaster displacement
Internal displacement impacts housing, livelihoods, health and overall wellbeing. For many people, these impacts extend beyond the moment of movement. However, they remain difficult to quantify and are therefore often overlooked in decision-making.
core +1 more source
Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source
Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias +3 more
wiley +1 more source
Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park +5 more
wiley +1 more source

