Results 41 to 50 of about 1,852,748 (302)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Thymic rebound after adjuvant chemotherapy in breast cancer: a case report

Future Science OA
Chemotherapy, especially for malignant tumors, can affect the thymus, leading to its atrophy and a decreased production of naïve T lymphocytes. However, regenerative process can occur in children and rarely in adults manifesting as thymic hyperplasia.
Myriam Ayari, Sarah Ben Azouz, Amira Chehaider, Sarra Ben Rejeb, Taieb Jomni   +4 more
doaj   +1 more source

Investigation of Neurological Complications after COVID-19 Vaccination: Report of the Clinical Scenarios and Review of the Literature

Vaccines, 2023
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in 2019 and became a pandemic in 2020. Since then, vaccines have been approved to prevent severe illness.
Wei-Ping Chen, Ming-Hua Chen, Shih-Ta Shang, Yung-Hsi Kao, Kuo-An Wu, Wen-Fang Chiang, Jenq-Shyong Chan, Hann-Yeh Shyu, Po-Jen Hsiao   +8 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Understanding depletion forces beyond entropy

, 1999
The effective interaction energy of a colloidal sphere in a suspension containing small amounts of non-ionic polymers and a flat glass surface has been measured and calculated using total internal reflection microscopy (TIRM) and a novel approach within ...
A. D. Dinsmore, A. Sharma, B. Götzelmann, B. Götzelmann, C. Bechinger, D. C. Prieve, D. Haughey, D. L. Sober, D. Rudhardt, D. Rudhardt, D. Rudhardt, J. C. Crocker, J. Israelachvili, J. Janzen, K. Devanand, K. Mayer, P. Leiderer, R. Roth, S. Asakura, S. Dietrich, S. Tanimoto, Y. Mao, Y. N. Ohshima, Y. Rosenfeld   +23 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Wetting gradient induced separation of emulsions: A combined experimental and lattice Boltzmann computer simulation study

, 2008
Guided motion of emulsions is studied via combined experimental and theoretical investigations. The focus of the work is on basic issues related to driving forces generated via a step-wise (abrupt) change in wetting properties of the substrate along a ...
Raabe, Dierk, Stamm, Manfred, Truman, Pagra, Uhlmann, Petra, Varnik, Fathollah, Wu, Bin   +5 more
core   +1 more source

Force steps during viral DNA packaging ? [PDF]

, 2003
Biophysicists and structural biologists increasingly acknowledge the role played by the mechanical properties of macromolecules as a critical element in many biological processes.
Alberts, Boal, Bray, Bustamante, Cerritelli, Doi, Earnshaw, Earnshaw, Freund, Goldstein, Jané Kondev, Kindt, Lo, Meyers, Odijk, Parsegian, Prashant K. Purohit, Ptashne, Purohit, Raspaud, Rau, Rice, Riemer, Rob Phillips, Rosakis, Smith, Tao, Wang, Widom, Wikoff   +29 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Shell Deformation During the Construction of Record Span Soil-steel Buried Structure in Ras-Al-Khaimah (UAE)

Studia Geotechnica et Mechanica, 2023
The algorithm presented in this paper concerns the processing of data in the form of coordinates of measurement points located around the structure periphery, obtained from the geodetic measurements.
Machelski Czesław, Tomala Piotr
doaj   +1 more source