Results 51 to 60 of about 1,852,748 (302)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Decentralized force and motion control of multiple cooperative manipulators

open access: yesAutomatika, 2021
Decentralized force and motion control of a heavy object with lathing tools, in a cooperative multiple manipulator system is studied in this paper. Interaction of the object with robot manipulators and the environment and interaction of manipulators with
Hamid AzizZadeh   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Analytical Method for Determination of Internal Forces of Mechanisms and Manipulators

open access: yesRobotics, 2018
This paper presents a theory for the analytical determination of internal forces in the links of planar linkage mechanisms and manipulators with statically determinate structures, considering the distributed dynamic loads.
Muratulla Utenov   +4 more
doaj   +1 more source

Epistaxis, paroxysmal anxiety episodes, and hypertension in a child with SDHB‐associated paraganglioma: A case report

open access: yesClinical Case Reports, 2022
A child presented with anxiety and weight gain which were overlooked until she had epistaxis. She was found to have hypertension secondary to paraganglioma. She was managed with curative surgery involving multidisciplinary care.
Thinley Dorji, Vishesh Verma, Anil Menon
doaj   +1 more source

Thermodynamics in rotating systems -- analysis of selected examples

open access: yes, 2013
We solve a set of selected exercises on rotational motion requiring a mechanical and thermodynamical analysis. When non-conservative forces or thermal effects are present, a complete study must use the first law of thermodynamics together with the Newton'
Fiolhais, Manuel, Güémez, Julio
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Bubble-like structures generated by activation of internal shape modes in two-dimensional sine-Gordon line solitons

open access: yes, 2017
Nonlinear waves that collide with localized defects exhibit complex behavior. Apart from reflection, transmission, and annihilation of an incident wave, a local inhomogeneity can activate internal modes of solitons, producing many impressive phenomena ...
García-Ñustes, Mónica A.   +2 more
core   +1 more source

Anomalies of ac driven solitary waves with internal modes: Nonparametric resonances induced by parametric forces [PDF]

open access: yes, 2001
We study the dynamics of kinks in the $\phi^4$ model subjected to a parametric ac force, both with and without damping, as a paradigm of solitary waves with internal modes.
A. Sánchez   +27 more
core   +3 more sources

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