Results 61 to 70 of about 1,852,748 (302)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Vital Capacity and Selected Metabolic Diseases in Middle-Aged Japanese Men

Canadian Respiratory Journal, 2006
OBJECTIVE: To elucidate the association between vital capacity and the presence of selected metabolic diseases in middle-aged Japanese men.
Hidenari Sakuta, Takashi Suzuki, Hiroko Yyasuda, Teizo Ito   +3 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Right ventricular echocardiographic parameters predict severe sleep apnea syndrome in patients with heart failure [PDF]

Exploration of Medicine
Aim: The study aimed to determine which right ventricle echocardiography parameters were associated with severe sleep apnea syndrome in heart failure patients with sleep apnea syndrome.
Saoussen Antit, Ferdaous Yangui, Mariem Louati, Amine Boufares, Syrine Abdellatif, Mohamed Ridha Charfi, Lilia Zakhama   +6 more
doaj   +1 more source

Critique of a Pion Exchange Model for Interquark Forces [PDF]

, 1999
I describe four serious defects of a widely discussed pion exchange model for interquark forces: it doesn't solve the "spin-orbit problem" as advertised, it fails to describe the internal structure of baryon resonances, it leads to disastrous conclusions
A. B. Henriques, A. De Rújula, A. J. G. Hey, A. Le Yaouanc, A. Manohar, A. W. Thomas, C. Caso, C. D. Carone, C. D. Roberts, C. E. Carlson, C. E. Carlson, D. Faiman, D. Faiman, D. Gromes, D. Gromes, D. O. Riska, E. Witten, E. Witten, E. Witten, F. Butler, F. Butler, F. Gross, F. Gross, F. Gross, G. E. Brown, G. S. Bali, G. ’t Hooft, H. Collins, H. J. Schnitzer, H. J. Schnitzer, H. J. Schnitzer, J. Finger, J. Iizuka, J. Iizuka, L. Ya. Glozman, L. Ya. Glozman, L. Ya. Glozman, L. Ya. Glozman, L. Ya. Glozman, Lai-Him Chan, M. R. Frank, N. Brambilla, N. Isgur, N. Isgur, N. Isgur, N. Isgur, N. Isgur, N. Isgur, N. Isgur, N. Isgur, N. Isgur, N. Isgur, Nathan Isgur, P. Geiger, P. Geiger, P. Geiger, P. Geiger, P. Geiger, P. Geiger, P. Maris, P. Maris, R. Koniuk, R. Koniuk, S. Capstick, S. Godfrey, S. Okubo, S. Okubo, T. Schäfer, Y. Nambu, Y. Nambu   +69 more
core   +5 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Systematic review of scapular Ewing’s sarcoma and a rare case of massive pleural effusion as primary manifestation

Future Science OA
Background Ewing Sarcoma (ES) ranks second among mesenchymal malignancies in children and young adults. Scapular Ewing sarcoma (SES) represents
Hela Cherif, Haifa Ben Romdhane, Sarra Ben Rejeb, Soumaya Debiche, Mehdi Charfi, Ferdaous Yangui, Imen Bouassida, Salma Mokaddem, Mohamed Ridha Charfi   +8 more
doaj   +1 more source

Confining forces

, 2015
We discuss the forces on the internal constituents of the hadrons based on the bag model. The ground state of the hadrons forms a color singlet so that the effects of the colored internal states are neutralized.
Miller, David E., Rollmann, Dirk
core  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source