Results 61 to 70 of about 7,767,277 (394)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Integrating HIV care into primary care services: quantifying progress of an intervention in South Africa.

open access: yesPLoS ONE, 2013
BackgroundIntegration of human immunodeficiency virus (HIV) care into primary care services is one strategy proposed to achieve universal access to antiretroviral treatment (ART) for HIV-positive patients in high burden countries.
Kerry E Uebel   +4 more
doaj   +1 more source

Dimensional hyper-reduction of nonlinear finite element models via empirical cubature [PDF]

open access: yes, 2017
We present a general framework for the dimensional reduction, in terms of number of degrees of freedom as well as number of integration points (“hyper-reduction”), of nonlinear parameterized finite element (FE) models.
Caicedo Silva, Manuel Alejandro   +2 more
core   +2 more sources

MACROECONOMIC VOLATILITY AND INTERNATIONAL INTEGRATION

open access: yesBulletin of Economic Research, 2014
ABSTRACTThis paper explores the effects that varying degrees of international openness have on macroeconomic volatility. The analysis is conducted for a two‐symmetric‐country world under three levels of international integration: that of a closed economy, a financial autarky, and full financial integration.
openaire   +4 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Whose Needs Does Service Serve? Complicating the Citizen Soldier Narrative [PDF]

open access: yes, 2016
The growth of conscript militaries was integral to the creation of civil rights in European nation-states, which established militaries as a key site of claims-making.
Lair, Hannah
core   +5 more sources

Investment climate and international integration [PDF]

open access: yesWorld Development, 2006
Drawing on recently completed firm-level surveys in Bangladesh, Brazil, China, Honduras, India, Nicaragua, Pakistan, and Peru, this paper investigates the relationship between investment climate and international integration. These standardized surveys of large, random samples of firms in common sectors reveal how firms experience bottlenecks and ...
Dollar, David   +2 more
openaire   +2 more sources

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

The laminar integration of sensory inputs with feedback signals in human cortex [PDF]

open access: yes, 2017
The cortex constitutes the largest area of the human brain. Yet we have only a basic understanding of how the cortex performs one vital function: the integration of sensory signals (carried by feedforward pathways) with internal representations (carried ...
Muckli, Lars, Petro, Lucy S.
core   +1 more source

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