Results 61 to 70 of about 398,308 (298)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Fovea-sparing internal limiting membrane peeling with inverted flap technique versus standard internal limiting membrane peeling for symptomatic myopic foveoschisis

Scientific Reports
To study the long-term outcomes of standard ILM peeling and fovea sparing with inverted flap (FSIF) peeling for symptomatic myopic foveoschisis (MF).
Antonio Polito, Giulio Garruto, Emilia Maggio, Maurizio Mete, Massimo Guerriero, Grazia Pertile   +5 more
doaj   +1 more source

Inverted internal limiting membrane insertion combined with air tamponade in the treatment of macular hole retinal detachment in high myopia: study protocol for a randomized controlled clinical trial

Trials, 2018
Background Macular hole retinal detachment (MHRD) occurs most commonly in high myopia and causes severe visual impairment and greatly reduces the quality of life.
Ying Zheng, Mei Kang, Hong Wang, Haiyun Liu, Tao Sun, Xiaodong Sun, Fenghua Wang   +6 more
doaj   +1 more source

Barley plasma membrane intrinsic proteins (PIP aquaporins) as water and CO2 transporters [PDF]

, 2008
We identified barley aquaporins and demonstrated that one, HvPIP2;1, transports water and CO2. Regarding water homeostasis in plants, regulations of aquaporin expression were observed in many plants under several environmental stresses. Under salt stress,
C Zhu, DT Clarkson, DT Luu, E Zelazny, F Chaumont, GJ Cooper, GP Bienert, I Terashima, J Flexas, J Sakurai, J Takano, JF Ma, JY Jang, K Fetter, K Sato-Nara, LH Liu, M Katsuhara, M Katsuhara, M Katsuhara, M Katsuhara, Maki Katsuhara, N Uehlein, NL Nakhoul, P Kjellbom, R Aharon, R Vandeleur, S Suga, S Törnroth-Horsefield, SD Tyerman, TP Jahn, U Johanson, X Yang, YT Hanba, Yuko T. Hanba   +33 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Extracorporeal membrane oxygenation simulation-based training: methods, drawbacks and a novel solution [PDF]

, 2018
Introduction: Patients under the error-prone and complication-burdened extracorporeal membrane oxygenation (ECMO) are looked after by a highly trained, multidisciplinary team.
Abbes Amira, Abdullah Alsalemi, Alsalemi A, Brindley PG, Fayçal Bensaali, Guillaume Alinier, Lansdowne W, Lazzeri C, Mohammed Al Disi, Morris RW, Yahya Alhomsi   +10 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Retinal thickness after vitrectomy and internal limiting membrane peeling for macular hole and epiretinal membrane

Clinical Ophthalmology, 2012
Kazuyuki Kumagai1, Nobuchika Ogino1, Mariko Furukawa2, Masanori Hangai3, Shigeyasu Kazama1, Shirou Nishigaki4, Eric Larson51Shinjo Ophthalmologic Institute, Miyazaki, 2Department of Ophthalmology, Kami-iida First General Hospital, Nagoya, 3Department of ...
Kumagai K, Ogino N, Furukawa M, Hangai M, Kazama S, Nishigaki S, Larson E   +6 more
doaj  

Electrodeposition of arrays of Ru, Pt, and PtRu Alloy 1D metallic nanostructures [PDF]

, 2010
Arrays of Ru, Pt, and PtRu one dimensional 1D nanowires NWs and nanotubes NTs were prepared by electrodeposition through the porous structure of an anodic aluminum oxide AAO membrane.
Garbarino, Sébastien, Guay, Daniel, Ponrouch, Alexandre, Pronovost, Stéphanie, Simon, Patrice, Taberna, Pierre-Louis   +5 more
core   +2 more sources