Results 51 to 60 of about 543,530 (306)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

HUBUNGAN ANTARA KECERDASAN EMOSIONAL DAN INTERNAL LOCUS OF CONTROL DENGAN PERILAKU PROSOSIAL PADA PELAJAR DI SMA NEGERI 10 YOGYAKARTA

Insight: Jurnal Ilmiah Psikologi, 2015
Penelitian ini bertujuan untuk mengetahui mengetahui hubungan antara kecerdasan emosional dan internal locus of control dengan perilaku prososial pada pelajar di SMA Negeri 10 Yogyakarta.
Meidy Dewita Artianasari Noija, Kamsih Astuti   +1 more
doaj   +1 more source

PENGARUH LOCUS OF CONTROL DAN SISTEM PENGENDALIAN INTERNAL TERHADAP BUDGETARY SLACK (Studi pada PT Kereta Api Indonesia (Persero) Kota Bandung) [PDF]

, 2018
ABSTRACK Penelitian ini bertujuan untuk mengetahui seberapa pengaruh antara Locus of Control dan Sistem pengendalian Internal terhadap Budgetary Slack pada PT Kereta Api Indonesia (Persero) Kota Bandung.
Pembimbing I, Dr. H. Sasa. S. Suratman., SE., MSc., AK., CA, Shabira Amani Mustofa, 144020110   +1 more
core  

The Role of Psychosocial Factors in Wellbeing and Self-Care in Young Adults with Type 1 Diabetes [PDF]

, 2012
The purpose of this study is to explore the relationship between glycaemic control, locus of control beliefs, diabetes knowledge and wellbeing in young adults with type 1 diabetes. A cross-sectional study of forty-two young adults (16-25 years) with type
Evangeli, M., Pires-Yfantouda, R.
core   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Locus of Control and Job Search Strategies [PDF]

Standard job search theory assumes that unemployed individuals have perfect information about the effect of their search effort on the job offer arrival rate. In this paper, we present an alternative model which assumes instead that each individual has a
Caliendo, Marco, Cobb-Clark, Deborah A., Uhlendorff, Arne   +2 more
core   +3 more sources

The impact of prenatal parental locus of control on children's psychological outcomes in infancy and early childhood:a prospective 5 year study [PDF]

, 2017
Locus of control is one of the most widely studied concepts in the history of personality psychology. In spite of its popularity and its associations with numerous relevant outcomes, the ability of locus of control to predict future behaviors involving ...
Ellis, Genette, Golding, Jean, Gregory, Steve, Iles-Caven, Yaz, Nowicki, Stephen   +4 more
core   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Internal Locus of Control and Self-Concept as Factors Affecting the Career Maturity of High School Students

International Journal of Research in Counseling and Education, 2018
Determining the choice of jobs or education choices is one of the tasks during the development of the senior high school. For that, high school students are required to understand and master the concepts of career maturity to be able to pick and choose ...
Munawir Munawir, A. Muri Yusuf, Z. Mawardi Effendi, Afdal Afdal   +3 more
doaj   +1 more source