Results 141 to 150 of about 5,340,255 (247)

Diverse ossification pathways in the lower jaw of Sclerocephalus (Lower Permian) as revealed by the first record of chondroid bone in Amphibia. [PDF]

Sci Rep
Konietzko-Meier D, Klein N.
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

The Morphology of the Anterior Segment and Periorbita of the Great Horned Owl (Bubo virginianus). [PDF]

J Morphol
Murphy CJ, Howland H, Evans H, Cummings JC, Moore BA.   +4 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Development and Validation of an LC-MS/MS Method for the Quantification of HY-078020 in Human Plasma Using Liquid-Liquid Extraction and Its Application to Human Pharmacokinetic Study. [PDF]

Biomed Chromatogr
Wang Y, Zhang M, Cui Y, Shao L, Meng L, Chen M, An M, Shen Z, Chu Z.   +8 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Preparation of Internal Mammary Vessels Using Ultrasonic Energy: A Technical Note

Plastic and Reconstructive Surgery, Global Open
Abdullah Z. AlQhtani, MD, Perez Rocio, MD, Hyungbae Kim, MD, PhD, Hyun Ho Han, MD, PhD   +3 more
doaj   +1 more source

Cross-cultural adaptation and psychometric validation of the Kannada version of the Extended Effort Assessment Scale (EEAS-K) in adults with hearing loss. [PDF]

PLoS One
Rhythm B, Ganapathy K, Gundmi A, Palaniswamy HP.   +3 more
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Correction: Development and validation of the organizational health behavior index: a mixed-methods instrument for measuring organizational health. [PDF]

Front Psychol
Alzuman A, Jaafari MA, Ali Z, Ali R, Bakadam LI.   +4 more
europepmc   +1 more source