Results 51 to 60 of about 2,891,548 (204)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

THE EFFECT A LEVELS OF CINNAMON (CINNAMOMUM BURMANII) LEAVES EXTRACT IN THE DIET ON INTERNAL ORGANS WEIGHT AND ABDOMINAL FAT OF BROILERS [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences, 2022
This research aims to determine the effect of level of Cinnamon (Cinnamomum burmanii) leaves extract on the diet to internal organs broilers. The study used an experimental method with a completely randomized design (CRD) with six treatments and four ...
Suyudi L., Sudjarwo E., Sjofjan O.
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

EFFECT OF ADDING MIXTURE OF MINT, CINNAMON AND ASTRAGALUS TO BROILER DIETS ON PHYSIOLOGICAL TRAITS UNDER HEAT STRESS

The Iraqi Journal of Agricultural science
This experiment was conducted to investigate the effect of adding mixture of medical plant to broiler diets on some physiological traits under heat stress conditions.
Alii Al-Azzawi, Hasanain Ezzat
doaj   +1 more source

AILIB-BODY_021 - BODY: internal organs

BODY: internal organs, old scan: J17.

core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Variants and anomalies of the female genital internal organs [PDF]

, 2008
Catedra Anatomia OmuluiThe objective of this research is to study and analyze the forms, sizes and position variants of the female genital internal organs.
Leanca, Anna
core   +1 more source

Practicum in Propedeutics to Internal Medicine for 3rd year students of 6th medical faculty. Module 2: Symptoms and syndromes in internal organs diseases

, 2015
Practicum in Propedeutics to Internal Medicine “Symptoms and syndromes in internal organs diseases”Practicum in Propedeutics to Internal Medicine “Symptoms and syndromes in internal organs ...
Vizir, Maryna, Kovalyova, Olga, Pytetskaya, Natalia, Demydenko, Ganna, Honchar, Oleksii, Ashcheulova, Tetyana, Kochubiei, Oksana   +6 more
core   +1 more source