Results 51 to 60 of about 451,415 (297)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Передгірне та гірське землеробство і тваринництво, 2022 The article is devoted to the study of the effect of feeding different amounts of triticale grain in the diet on digestibility of nutrients, body weight, average daily gain, carcass weight and slaughter yield of rabbits from 40 to 90 days of age. It was
М. V. HRYNІV +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Determining the activity of body meridians during static exercise
Здоров’я, спорт, реабілітація, 2019 The purpose of the work was to determine the means of acupuncture diagnosis according to the method of J. Nakatani, the effect of performing physical exercises on the body on an example of a static exercise, which is performed similarly to the Padmasana (
O.V. Musiyenko, N.P. Matsola, L. Mykhats
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Morphofunctional Aspects of Internal Organs in Chronic Alcoholism [PDF]
, 2023 It has been established that in the structure of mortality in recent years, death from chronic alcoholism and acute alcohol intoxication, as well as associated complications, occupies a leading position, second only to mortality from cardiovascular ...
Halimova, Yu. S.
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Ветеринария сегодня, 2021 Enzootic bovine leukosis has been an urgent problem of veterinary medicine both in the Russian Federation and abroad for more than a hundred years. A number of aspects have been studied quite deeply; however, there are still areas that require additional
E. S. Krasnikova +3 more
doaj +1 more source