Results 91 to 100 of about 4,618,698 (308)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Effects of Dietary Supplementation of Humic Substances on External and Internal Egg Quality of Oravka Hens

Scientific Papers Animal Science and Biotechnologies, 2023
The aim of this study was to appraise the effect of humic substances (HS) in different concentrations on external and internal egg quality of laying hens. In total, 20 Oravka hens were allocated to 4 treatments, each containing 5 birds. The control birds
Cyril Hrnčár, Emília Hanusová, Anton Hanus, Lukáš Zita, Nikoleta Šimonová, Terézia Hegerová, Jozef Bujko   +6 more
doaj  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Quality Assurance: National and International

Journal of Food Protection, 1981
In this age of instant communication, product quality complaints or adverse publicity originating from any point on the globe can have potentially world-wide repercussions and devastating effects on any firm operating on an international basis. For this reason, effective Quality Assurance must ensure that all products made by a firm throughout the ...
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Physiological Responses and Determination of Harvest Maturity in ‘Daehong’ Peach According to Days After Full Bloom

Horticulturae
This study examined the physiological development of the red-fleshed peach cultivar ‘Daehong’ at different stages of fruit maturation to determine the optimal harvest time.
Yoo Han Roh, In-Lee Choi, Joo Hwan Lee, Yong Beom Kwon, Hyuk Sung Yoon, Haet Nim Jeong, Ho-Min Kang   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Variation Law and Predictive Modeling Construction of Internal Quality in Korla Fragrant Pears Under Multi-Type Damage During Storage

Horticulturae
To enhance the economic benefits of the Korla fragrant pear industry and reduce fruit loss rates, this study investigates changes in pear fruit quality during storage under different damage types.
Yifan Xia, Hong Zhang, Jikai Che, Qing Liang, Yang Liu   +4 more
doaj   +1 more source

Vortices within vortices: hierarchical nature of vortex tubes in turbulence

, 2013
The JHU turbulence database [1] can be used with a state of the art visualisation tool [2] to generate high quality fluid dynamics videos. In this work we investigate the classical idea that smaller structures in turbulent flows, while engaged in their ...
Bürger, Kai, Eyink, Gregory L, Lalescu, Cristian C, Meneveau, Charles, Szalay, Alexander, Treib, Marc, Werner, Suzanne, Westermann, Rüdiger   +7 more
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