Results 161 to 170 of about 10,248,575 (312)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Longitudinal Sigma-Metric Profiling of Two Clinical Chemistry Platforms Using Peer-Group Internal Quality Control. [PDF]

Diagnostics (Basel)
Meyliza I, Aryati A, Marpaung FR.
europepmc   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Optimized machine learning and artificial neural networks for NIRS-based prediction of mango internal quality. [PDF]

Sci Rep
Kusumiyati K, Sutari W, Supratman U, Munawar AA, Putri IE, Hadiwijaya Y.   +5 more
europepmc   +1 more source

Detection of Mildewed Nutmeg Internal Quality during Storage Using an Electronic Nose Combined with Chemical Profile Analysis. [PDF]

Molecules, 2023
Cui Y, Yao Y, Yang R, Wang Y, Liang J, Ouyang S, Yu S, Zou H, Yan Y.   +8 more
europepmc   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Internal Revenue Service annual report.

, 1999
Title from cover.Initial issue covers two fiscal years.Mode of access: Internet.Produced by: Strategic Planning and Communications 1993-1994; by: IRS Communications Division, 1995-Contains statistical tables and organizational information previously ...
United States. Internal Revenue Service., United States. Internal Revenue Service. Communications Division., United States. Internal Revenue Service. Strategic Planning and Communications.   +2 more
core  

Risk-based redesign of internal quality control procedures for emergency immunoassays in clinical laboratories: a multicenter study from China. [PDF]

Front Med (Lausanne)
Xiao G, Hu J, Liu Y, Zhao S, Liao W, Wang H, Zhang S.   +6 more
europepmc   +1 more source

Testing the stability of internal quality controls stored in the automated Atellica Solution refrigerated storage module. [PDF]

Adv Lab Med, 2023
Rayo Hidalga P, Domingo Bautista C, Fernandez Bonifacio R, Bedini Chesa JL, Santana NR.   +4 more
europepmc   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source