Results 61 to 70 of about 10,248,575 (312)

A multidisciplinary care pathway improves quality of life and reduces pain in patients with fibrous dysplasia/McCune-Albright syndrome: a multicenter prospective observational study

Orphanet Journal of Rare Diseases, 2022
Background Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) may cause pain, impaired ambulation and decreased quality of life (QoL). International guidelines advocate management of FD/MAS in a tertiary multidisciplinary care pathway, but no ...
Maartje E. Meier, Marlous Hagelstein-Rotman, Annenienke C. van de Ven, Ingrid C. M. Van der Geest, Olav Donker, Sarina E. C. Pichardo, Petra C. E. Hissink Muller, Stijn W. van der Meeren, Desirée M. J. Dorleijn, Elizabeth M. Winter, Michiel A. J. van de Sande, Natasha M. Appelman-Dijkstra   +11 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Effects of different types of fruit bags on the quality of Xiahui 10 peaches [PDF]

Guoshu xuebao
[Objective] Fruit bagging is a common practice used by growers to improve fruit quality, prevent pest and disease infestations, avoid direct pesticide contamination, enhance edibility, improve appearance, increase commercial value and raise market ...
ZHANG Binbin, DU Jinhua, CHEN Hong, WANG Xiaojun, ZHANG Yuanyuan, CHEN Zheng, DING Hui, YAN Zhimei, YU Mingliang, MA Ruijuan   +9 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Effects of Dietary Supplementation of Humic Substances on External and Internal Egg Quality of Oravka Hens

Scientific Papers Animal Science and Biotechnologies, 2023
The aim of this study was to appraise the effect of humic substances (HS) in different concentrations on external and internal egg quality of laying hens. In total, 20 Oravka hens were allocated to 4 treatments, each containing 5 birds. The control birds
Cyril Hrnčár, Emília Hanusová, Anton Hanus, Lukáš Zita, Nikoleta Šimonová, Terézia Hegerová, Jozef Bujko   +6 more
doaj  

Metabolites of non-aureus staphylococci affect the ability of Staphylococcus aureus to adhere to and internalize into bovine mammary epithelial cells

Veterinary Research, 2023
This study investigated whether cell-free supernatants (SN) from four bovine non-aureus staphylococcal (NAS) isolates prevent Staphylococcus aureus adhesion to and internalization into bovine mammary epithelial cells (MAC-T cells) and if so, to determine
Bruno Toledo-Silva, Ana Cláudia Dumont Oliveira, Fernando N. Souza, Freddy Haesebrouck, Sarne De Vliegher   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

LA RESONANCIA MAGNÉTICA Y SUS APLICACIONES EN LA AGROINDUSTRIA, UNA REVISIÓN THE MAGNETIC RESONANCE AND ITS AGRO-INDUSTRY APPLICATIONS, A REVIEW

Revista Facultad Nacional de Agronomía Medellín, 2007
Las propiedades electromagnéticas que presentan el hidrógeno y otros núcleos que componen los productos agroalimentarios han permitido usar ampliamente la Resonancia Magnética (RM) para estudiar, de manera no destructiva, la composición y la estructura ...
Iván Darío Aristizábal Torres
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source