Results 21 to 30 of about 321,305 (257)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Transformation of the State Finance Control System in Ukraine: The Status, Challenges and Prospects [PDF]
Облік і фінанси, 2020 At the end of 2019, the reform of the state financial control body was announced – the transformation of the State Audit Service of Ukraine into the Office of Financial Control with drastic changes in functions and powers and a significant reduction of ...
Yuliya Slobodianyk
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Improving Internal Audit in the Public Sector
Учёт. Анализ. Аудит, 2019 The transition to a digital economy, as well as structural changes generated in connection with this and a set of theoretical, methodological and practical issues related to the development of organizational and methodological support of subjects of ...
D. R. Giniyatullina
doaj +1 more source
Organisation of Internal Controls and Financial Audits in the Public Sector Organisations
Учёт. Анализ. Аудит, 2023 The purpose of the study is to analyze the problems associated with the way internal control and financial auditing are organised in budgetary and public sector organisations.
I. D. Demina, T. I. Krishtaleva
doaj +1 more source
STATE AND PROSPECTS OF DEVELOPMENTOF THE INTERNAL FINANCIAL CONTROL SYSTEM IN BUDGETARY INSTITUTIONS
Bulletin of Taras Shevchenko National University of Kyiv. EconomicsB a c k g r o u n d. In the modern economic environment significant importance is given to state financial control, which is undergoing modernization as one of the components of the state finance system. Currently, the situation in this area is quite unfavorable due to military conflict and aggression from russia, corruption, ineffective management ...
Tetiana MELNYK +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source