Results 121 to 130 of about 3,406 (225)

Global Pharmaceutical Regulation: Comparative Frameworks and Operations. [PDF]

Pharmacy (Basel)
Umaru OT, Adeyemi AS, Aderonmu O, Bhangu BS, Dhaliwal HS, Lim H, Aremu TO.   +6 more
europepmc   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Estimating long-term care needs in data-scarce settings: a diagnostic model with evidence from MENA. [PDF]

Popul Health Metr
Ismail M, Kanth PD, Hussein S.
europepmc   +1 more source

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

The ⁶⁸Ge/⁶⁸Ga generator for enhancing productivity and reducing costs in nuclear medicine: experience from a university hospital. [PDF]

EJNMMI Radiopharm Chem
Guercio A, Martin T, Migliari S, Gagliardi A, Scarlattei M, Baldari G, Martelli N, Ruffini L.   +7 more
europepmc   +1 more source

Effect of esomeprazole on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader, in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this study is to evaluate the effects of multiple doses of esomeprazole, a strong proton pump inhibitor and acid‐reducing agent, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader.
Lana Tran, Naihan Chen, Jennifer A. Winton, Kyle T. Matschke, Smita P. Goodman, Kimberly C. Lee, Yuanyuan Zhang, Weiwei Tan   +7 more
wiley   +1 more source

Clinical Pharmacokinetics, Mass Balance and Metabolism of Fezolinetant in Postmenopausal Women. [PDF]

Eur J Drug Metab Pharmacokinet
Iwai M, Souda K, Miyagawa M, Nielsen JC, Chappa A, Fraser GL, Ramael S, Brouwer JLP, Huang J.   +8 more
europepmc   +1 more source

Standardization of measurement and reporting of medication adherence using the TEN‐SPIDERS tool for claims data

British Journal of Clinical Pharmacology, EarlyView.
This study provides the first open‐source tool to implement the complete TEN‐SPIDERS framework in linked datasets for the determination of the PDC for medication adherence. The TEN‐SPIDERS tool enables transparent, reproducible medication adherence research through automated reporting of all calculation parameters and flexible customization options ...
Adam C. Livori, Tzu‐Yung Kuo, Jenni Ilomäki, Monique F. Kilkenny, Stella Talic, Zanfina Ademi, J. Simon Bell, Jedidiah I. Morton, Lachlan L. Dalli   +8 more
wiley   +1 more source

Personalised Psychological Care in Hospitals: An Organisational Model of Integrated, Patient- and Staff-Centred Services (2019-2024). [PDF]

J Pers Med
Chieffo DPR, Massaroni V, Delle Donne V, Lafuenti L, Monti L, Arcangeli V, Moriconi F, Ferrarese D, Galluzzi R, Mercuri EM, Sani G, Tortora G, Gasbarrini A.   +12 more
europepmc   +1 more source

Building trust in the integration of artificial intelligence into chemical risk assessment: findings from the 2024 ECETOC workshop. [PDF]

Arch Toxicol
Gant TW, Boxall A, Burgwinkel D, Zare Jeddi M, Djidrovski I, Friedrichs S, Hardy B, Hartung T, Holland D, Karwath A, Kienhuis A, Kleinstreuer N, Lin Z, Marczylo EL, Marvuglia A, Qian H, van Ravenzwaay B, Rees P, Sarimveis H, Tralau T, Wilmot L, Zalewski A, Rouquié D.   +22 more
europepmc   +1 more source