British Journal of Clinical Pharmacology, EarlyView.Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden +3 more
wiley +1 more source
Genotype Characteristics and Hearing Phenotype Analysis of Newborns with Biallelic GJB2 Mutations: A 652-Case-Cohort Study. [PDF]
Int J Neonatal ScreenLi J, Wu B, Liu W.
europepmc +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim Clinically, interstitial lung disease (ILD) is a heterogeneous group of respiratory disorders. Due to their low incidence, pharmacovigilance database analysis is useful to detect them. Precise diagnosis is challenging as well as coding in these databases. Query criteria are among the key elements for a good signal detection.
Romane Freppel +4 more
wiley +1 more source
A scientometric dataset on pharmaceuticals and illicit drugs (including cocaine) in the water resources of Latin America and the Caribbean (1990-2024). [PDF]
Data BriefRoveri V +5 more
europepmc +1 more source
Medical versus science students: Knowledge, perceptions and learning of core pharmacology concepts
British Journal of Clinical Pharmacology, EarlyView.Aims Pharmacology is a core discipline underpinning both medical and biomedical science education, essential for understanding drug action, safety and therapeutic efficacy. This study compared pharmacology knowledge, perceptions and learning experiences between second‐year medical and science students to evaluate how effectively each curriculum ...
Zina Alfahl +3 more
wiley +1 more source
Evolving health policy and regulatory oversight of medicinal cannabis in Australia: lessons for sustainable integration. [PDF]
J Cannabis ResLim ECN, Lim CED.
europepmc +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong +6 more
wiley +1 more source
Veterinary medicinal product regulation in sub-Saharan Africa: identifying barriers and opportunities for enhancing VMP regulatory systems. [PDF]
Front Vet SciPyatt AZ +4 more
europepmc +1 more source
British Educational Research Journal, EarlyView.Abstract This paper analyses differences in academic achievement associated with attendance at publicly funded private schools and public schools across 11 European countries. Using eight waves of PISA data (2000–2022), we apply OLS, IPW and IPWRA estimators to account for observed heterogeneity and mitigate selection bias.
Priya Maurya +2 more
wiley +1 more source
Translating and testing feasibility and reliability of the Clinical Frailty Scale for assessing older adults in Greenland. [PDF]
Int J Circumpolar HealthFricke CH +5 more
europepmc +1 more source