Results 61 to 70 of about 1,427,992 (257)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The Journal for Transdisciplinary Research in Southern Africa, 2014 Many countries experience various degrees of corruption. South Africa is no exception. The undeniable fact is that corruption cannot be reckoned as a mere country- or region- specific problem; it is a far wider phenomenon.
Thozama Majila +2 more
doaj +1 more source
Bibliographic Control Within Lithuanian Integrated Library Information System [PDF]
, 2006 After the restoration of Lithuania’s sovereignty, bibliographic control of Lithuanian documents was immediately initiated, and this function was assigned to the Martynas Mažvydas National Library of Lithuania in 1992 under the Resolution of the ...
Varnienė-Janssen, Regina
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
The importance of knowledge management in the decommissioning process
Radiation Protection and EnvironmentThe operational period of nuclear facilities often spans several decades, while disposal facilities are designed to operate for even longer periods.
Fernando B. Razuck
doaj +1 more source
Вестник Северо-Кавказского федерального университета, 2022 In this article the position of Russia is analyzed in the ratings of international organizations studying various aspects of the investment attraction of countries.
J. Lysenko, J. Konopleva
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MAIN CHARACTERISTICS OF RULES AND COMPETITION SYSTEMS IN GYMNASTICS FROM 1896 TO 1912
Science of Gymnastics Journal, 2014 The efforts for a subjective and fair judgment for Gymnastics began since the first decades of the 19th century i.e. since the sport began to take a primitive competition form.
Georgios Papadopoulos +3 more
doaj +1 more source