Results 91 to 100 of about 27,784,099 (375)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
A case study from Guyana of adapting engaged research design to promote ‘fairness in knowing’
Research for All, 2022 In this paper, we have combined ideas drawn from philosophy (epistemic injustice), critical theory (epistemicide) and practical approaches (engaged research design) with Indigenous knowledge to promote ‘fairness in knowing’ in a project called DETECT ...
doaj +2 more sources
Short-Term Labour Market Outlook and Key Challenges in G20 Countries [PDF]
, 2013 [Excerpt] The latest available forecasts from the IMF and the OECD point to a weak uptick in economic activity in 2013 and 2014. This will continue to hold back short-term employment growth and hinder progress towards the medium-term objective of ...
International Labour Office +1 more
core +1 more source
Using behavioral science to promote international development [PDF]
, 2017 https://issuu.com/behavioralsciencepolicyassociation/docs/v3i3_web_bryanhttps://issuu.com/behavioralsciencepolicyassociation/docs/v3i3_web_bryanhttps://issuu.com/behavioralsciencepolicyassociation/docs/v3i3_web_bryanhttps://issuu.com ...
Braithwaite, Jeanine +11 more
core +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
The development of technology education internationally [PDF]
, 2009 The development of technology education within countries and regions is set within the historical, cultural, and political environment. Curriculum, teacher education, and in fact educational research do not sit in isolation from these.
Jones, Alister
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Assessing 15 Proposals for Promoting Innovation and Access to Medicines Globally
Annals of Global Health, 2015 BackgroundThere is widespread recognition that the existing global systems for innovation and access to medicines need reform. Billions of people do not have access to the medicines they need, and market failures prevent new drugs from being developed ...
Steven J. Hoffman, Karen So
doaj +1 more source
Strengthening National Wheat and Rice Research Systems [PDF]
, 1987 Report of an international consultation on 'Strengthening National Agricultural Research Systems to Assume an International Role in Specific Areas of Wheat and Rice Research and Training' held in Rome January 26-28, 1987. The forward is by Idriss Jazairy,
International Fund for Agricultural Development
core
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source