Results 91 to 100 of about 10,625,748 (303)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Strengthening National Wheat and Rice Research Systems [PDF]

open access: yes, 1987
Report of an international consultation on 'Strengthening National Agricultural Research Systems to Assume an International Role in Specific Areas of Wheat and Rice Research and Training' held in Rome January 26-28, 1987. The forward is by Idriss Jazairy,
International Fund for Agricultural Development
core  

Impact Assessment of Biological Control-Based Integrated Pest Management in Rice and Maize in the Greater Mekong Subregion

open access: yesInsects, 2019
The impact and sustainability of two interventions that have been formulated to introduce integrated pest management (IPM) into rice and maize crops in Southwestern China, Laos, and Myanmar between 2011 and 2016, and were assessed at the end of 2017 ...
Dirk Babendreier   +10 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

International Consultation on the NARS Vision of International Agricultural Research [PDF]

open access: yes, 1994
Declaration, conclusions, and recommendations of a consultation among representatives of national agricultural research systems (NARS) in developing countries convened by IFAD in Rome in December 1994.
International Fund for Agricultural Development
core  

The International Politics of Legal Reforms: Hard Bilateralism, Soft Multilateralism and the World Bank’s “Doing Business” Indicators

open access: yesRevista Brasileira de Política Internacional, 2017
The Law and Development literature still debates on the role of international institutions in promoting legal reforms as a means of inducing economic growth.
Yi Shin Tang
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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