Results 51 to 60 of about 22,736,035 (402)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

An Evaluation of the Knight International Journalism Fellowships [PDF]

, 2011
Reviews the achievements of 2007-10 fellows, including government policy changes in response to reporting, networks and educational institutions created, and new funding leveraged; the projects' sustainability and attainment of goals; and lessons ...

core  

Mapping ICD-10 and ICD-10-CM Codes to Phecodes: Workflow Development and Initial Evaluation

JMIR Medical Informatics, 2019
Background The phecode system was built upon the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) for phenome-wide association studies (PheWAS) using the electronic health record (EHR). Objective The goal of this
Patrick Wu, A. Gifford, Xiangrui Meng, Xue Li, H. Campbell, Tim Varley, Juan Zhao, R. Carroll, L. Bastarache, J. Denny, E. Theodoratou, Wei-Qi Wei   +11 more
semanticscholar   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Implementation of free delivery policy in Ghana [PDF]

, 2005
This evaluation was undertaken as part of IMMPACT’s global efforts, funded by the Bill & Melinda Gates Foundation, the U.K. Department for International Development, the European Commission and U.S.
IMMPACT
core  

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

Portfolio Evaluation: Fwf International Programmes [PDF]

, 2018
The present evaluation focuses on the international programme portfolio of the Austrian Science Fund (FWF). We assess the appropriateness of the portfolio as well as of its design and management. In addition, we trace evidence for the impact of the international programmes.
Degelsegger-Marquéz, Alexander, Wagner, Isabella, Kroop, Sylvana, Rigby, John, Cox, Deborah, Hinze, Sybille, Donner, Paul, Adams, Jonathan   +7 more
openaire   +2 more sources

SemEval-2016 Task 1: Semantic Textual Similarity, Monolingual and Cross-Lingual Evaluation

International Workshop on Semantic Evaluation, 2016
Comunicacio presentada al 10th International Workshop on Semantic Evaluation (SemEval-2016), celebrat els dies 16 i 17 de juny de 2016 a San Diego, California.
Eneko Agirre, Carmen Banea, Daniel Matthew Cer, Mona T. Diab, Aitor Gonzalez-Agirre, Rada Mihalcea, German Rigau, Janyce Wiebe   +7 more
semanticscholar   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Mobile Application Usability: Heuristic Evaluation and Evaluation of Heuristics [PDF]

, 2016
Ger Joyce, Mariana Lilley, Trevor Barker, and Amanda Jefferies, 'Mobile Application Usability: Heuristic Evaluation and Evaluation of Heuristics', paper presented at AHFE 2016 International Conference on Human Factors, Software, and Systems Engineering ...
Barker, Trevor, Jefferies, Amanda, Joyce, Ger, Lilley, Mariana   +3 more
core   +2 more sources