Results 61 to 70 of about 18,757,809 (339)

Effective interventions for improving routine childhood immunisation in low and middle-income countries: a systematic review of systematic reviews

BMJ Open
Objective An umbrella review providing a comprehensive synthesis of the interventions that are effective in providing routine immunisation outcomes for children in low and middle-income countries (L&MICs).Design A systematic review of systematic ...
Shradha S Parsekar, Monica Jain, Shannon Shisler, Maren Duvendack, Maria Daniela Anda Leon   +4 more
doaj   +1 more source

8th AfrEA International Conference edition editorial

African Evaluation Journal, 2018
No abstract available.
Mark Abrahams, Florence E. Etta, Michele Tarsilla, Kambidima Wotela   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Using qualitative systems mapping to analyze the linkages between the behavioral and social (BeSD) determinants of routine childhood immunization in LMICs

BMC Public Health
Background Designing effective immunization programs requires a strong understanding of how the factors affecting vaccine uptake interplay. In this review, we analyze the relationships between the Behavioral and Social Drivers (BeSD) of routine ...
Lalitha Vadrevu, Shradha S. Parsekar, Monica Jain, Gunjan Taneja, Shekhar Menon   +4 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PROTOCOL: Interventions to Promote Inclusive Governance for Underserved Population in Sub‐Saharan Africa: An Evidence and Gap Map

Campbell Systematic Reviews
This Protocol for an Evidence and Gap Map (EGM) aims to identify, map, and provide an overview of the existing evidence and gaps in inclusive governance interventions for underserved populations in sub‐Saharan Africa.
Clarice Panyin Nyan, Sheila Agyemang Oppong, Takyiwaa Manuh, David Sarfo Ameyaw   +3 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

PROTOCOL: The Effects of Land Management Policies on the Environment and People in Low‐ and Middle‐Income Countries: A Systematic Review

Campbell Systematic Reviews
Addressing the climate change and biodiversity loss crises while ensuring livelihoods are not negatively affected is a matter that requires urgent action.
Pierre Marion, Ingunn Storhaug, Sanghwa Lee, Claudia Romero, Constanza Gonzalez Parrao, Birte Snilstveit   +5 more
doaj   +1 more source

Initial Feasibility of a Woman-Focused Intervention for Pregnant African-American Women

International Journal of Pediatrics, 2011
African-American women who use crack are vulnerable to HIV because of the complex social circumstances in which they live. Drug-abuse treatment for these women during pregnancy may provide time for changing risk behaviors.
Hendrée E. Jones, Nancy D. Berkman, Tracy L. Kline, Rachel Middlesteadt Ellerson, Felicia A. Browne, Winona Poulton, Wendee M. Wechsberg   +6 more
doaj   +1 more source