Results 71 to 80 of about 18,757,809 (339)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Depressive symptoms among women in Raqqa Governorate, Syria: associations with intimate partner violence, food insecurity, and perceived needs

Cambridge Prisms: Global Mental Health, 2019
Background.Raqqa Governorate, Syria has recently been affected by overlapping conflicts related to the Syrian Civil war and occupation by ISIS, resulting in widespread displacement and disruption of economic livelihoods.
K. L. Falb, A. Blackwell, J. Stennes, M. Hussein, J. Annan   +4 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Factors influencing household adaptive capacity and its association with food security in Somalia

Discover Sustainability
Building adaptive capacities is a crucial pathway to improving food security of households experiencing multiple shocks. Despite several studies documenting the effect of adaptive capacity on food security in the Horn of Africa, relatively little is ...
Conrad Murendo, Jerome Galagade, Kevin Paul Mackey, Nancy Mock, Beryl Oranga, Nishant Das, Aimable Nsengiyumva, Sandra Ndung’u, Donald Otieno Ochieng, Suganya Kimbrough   +9 more
doaj   +1 more source

Rubrics Methodology in Detail: Helping Save The Children Turn Children's Experiences of Discrimination and Exclusion into Rich, Trackable Outcomes

Journal of MultiDisciplinary Evaluation
Background: Save the Children’s child sponsorship program (referred to as Sponsorship) supports children, their families and communities, and institutions in 20 countries to create social and behavior change together so that all children survive, learn,
E. Jane Davidson, Thomaz Chianca, Nicole Dulieu, Anil Sigdel   +3 more
doaj   +1 more source

General service and child immunization-specific readiness assessment of healthcare facilities in two selected divisions in Bangladesh

BMC Health Services Research, 2018
Background Service readiness of health facilities is an integral part of providing comprehensive quality healthcare to the community. Comprehensive assessment of general and service-specific (i.e.
Md. Shajedur Rahman Shawon, Gourab Adhikary, Md. Wazed Ali, Md. Shamsuzzaman, Shahabuddin Ahmed, Nurul Alam, Katya A. Shackelford, Alexander Woldeab, Stephen S. Lim, Aubrey Levine, Emmanuela Gakidou, Md. Jasim Uddin   +11 more
doaj   +1 more source

What is the optimal assessment of speech? A multicentre, international evaluation of speech assessment in 2500 patients with a cleft. [PDF]

BMJ Open, 2023
Ombashi S, Kurniawan MS, Allori A, Sharif-Askary B, Rogers-Vizena C, Koudstaal M, Franken MC, Mink van der Molen AB, Mathijssen I, Klassen A, Versnel SL.   +10 more
europepmc   +1 more source

Evaluation of Russia’s Nuclear Weapons Program in Terms of International Nuclear and Commercial Law [PDF]

, 2022
Metin KIRATLI, Zhuldyz KANAPİYANOVA
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Government Bonds and COVID-19. An International Evaluation Under Different Market States. [PDF]

Eval Rev, 2023
Jareño F, Martínez-Serna MI, Chicharro M.   +2 more
europepmc   +1 more source