Results 111 to 120 of about 49,003 (308)

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Rethinking Jurisdiction in International Law [PDF]

, 2014
Jurisdiction has traditionally been considered in international law as purely a question of the rights and powers of states. Conceived in this way, the rules on jurisdiction serve the important function of delimiting (while accepting some overlap of ...
Mills, A
core  

Cost‐effectiveness of DPYD genotyping prior to fluoropyrimidine‐based treatment for colorectal cancer in Wales

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton, Sian M. Morgan, Richard A. Adams, Samantha Cox, Angharad A. Rudkin, Megan Fealey, Craig Barrington, Michelle D. Wood, Dyfrig A. Hughes   +8 more
wiley   +1 more source

Limits of Jurisdiction of International Courts and Tribunals Vis-à-vis the CJEU under EU Law

Ankara Avrupa Çalışmaları Dergisi
The article examines, within the context of compatibility with the autonomy of the EU legal order of dispute settlement mechanisms established or designated by agreements, the boundaries of jurisdiction of international courts/tribunals drawn by the CJEU
Mustafa Tayyar Karayiğit
doaj   +1 more source

‘Where are the adults?’: Troubling child‐activism and children's political participation

British Educational Research Journal, EarlyView.
Abstract Children's political participation is a well‐established theme in childhood studies. In this article we offer an original account of child activism that takes into account the entangled and emergent aspect of children as activists. We begin with a historical and a conceptual review, noting the importance of mid‐20th century developments such ...
Sharon Hunter, Claire Cassidy
wiley   +1 more source

Hong Kong's non‐local undergraduate recruitment: Policies, institutional practices and student perspectives

British Educational Research Journal, EarlyView.
Abstract Beneath the Hong Kong government's enthusiasm for recruiting non‐local undergraduates—including students from the Chinese Mainland and other international regions—lies a longstanding gap in understanding the core meanings and drivers shaping the territory's expanding focus on inward international student mobility (ISM).
Fang Gao, Wei Yan Xiong, Hei‐hang Hayes Tang, Xiao Han   +3 more
wiley   +1 more source

Moderators' perceptions of consistency in Key Stage 2 writing moderation across local authorities

British Educational Research Journal, EarlyView.
Abstract This article explores moderators’ perceptions of the consistency of Key Stage 2 (KS2) writing moderation across Local Authorities (LAs) in England, a process central to securing the reliability and fairness of teacher assessment in a high‐stakes accountability system.
Rebecca Clarkson
wiley   +1 more source

Restoring Trust: Rebuilding the Forest Carbon Credit System Through Scientific Rigor

Biological Diversity, EarlyView.
ABSTRACT As pivotal nature‐based climate solutions (NbCS), forests are increasingly recognized for their climate mitigation potential. However, this potential is undermined by fundamental flaws in current carbon credit systems. Our analysis identifies four interconnected systemic challenges: (1) subjective additionality assessments arising from ...
Xiaoqian Chen, Shaokun Li
wiley   +1 more source

Jurisdiction in, and the law applicable to, cross-border contractual obligations: the objectives and impact of the EU's legislative journey

, 2014
This thesis researches EU private international law rules relating to contracts, including its historical development, its rules and its policy objectives.
Strecker, S
core  

Transforming Brain Health With Neurotechnology Convergence (Part II): Intelligent Neurointervention Systems for Neurological Disorders

Brain Health, EarlyView.
ABSTRACT Neurological disorders represent a critical domain within global health, necessitating advanced interventions to address complex pathologies such as tumors, functional disorders, and cerebrovascular diseases. Despite the proven benefits of early intervention, current treatment paradigms face significant challenges: (1) limited precision in ...
Qing Ye, Fei Peng, Chao Pan, Ping Zhang, Xuewei Xie, Zixiao Li, Yingxin Tang, Danyang Chen, Yuanwei Li, Jiawen Wu, Zao Han, Qing Dai, Quansheng Gu, Jizong Zhao, Zhouping Tang   +14 more
wiley   +1 more source