Results 41 to 50 of about 6,118,173 (371)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Migrant arrivals and deaths in the Mediterranean: what do the data really tell us?

Forced Migration Review, 2016
The policy and media gaze focuses on numbers of migrant arrivals and deaths. There are problems in the data for both categories.
Frank Laczko, Ann Singleton, Tara Brian , Marzia Rango   +3 more
doaj  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Xenophobia, International Migration and Human Development [PDF]

, 2009
In the continuing discussion on migration and development, the vulnerability of all migrant groups to exploitation and mistreatment in host countries has been highlighted along with an emphasis on protecting their rights.
Crush, Jonathan, Ramachandran, Sujata
core   +1 more source

Monitoring international migration flows in Europe. Towards a statistical data base combining data from different sources [PDF]

, 1993
The paper reviews techniques developed in demography, geography and statistics that are useful for bridging the gap between available data on international migration flows and the information required for policy making and research. The basic idea of the
A. B. Wils, A. B. Wils, A. G. Wilson, A. Lovett, A. M. Isserman, A. Ogilvy, A. P. Dempster, A. Rogers, A. Rogers, A. Rogers, A. Rogers, A. Rogers, A. Rogers, A. Speare, A. Vishnevsky, B. E. Flores, C. P. Schmertmann, C. T. Ireland, C. Wolfe, D. A. Plane, D. Bunn, D. C. Knudsen, D. Coleman, D. Courgeau, D. Courgeau, D. Courgeau, D. Courgeau, D. Friedlander, D. J. Kaa Van de, D. Kahnemann, E. C. MacRae, E. Hoffmann, E. Jaynes, E. P. Kraly, E. Ravenstein, E. Ravenstein, F. Ploeg van der, F. Snickars, F. Willekens, F. Willekens, F. Willekens, F. Willekens, F. Willekens, F. Willekens, F. Willekens, F. Willekens, F. Willekens, F. Willekens, F. Willekens, Frans Willekens, G. A. Carmichael, G. Hyman, H. Akaike, H. Entzinger, H. T. Eldridge, I. J. Good, J. A. Nelder, J. B. Lang, J. D. Kalbfleisch, J. D. Kasarda, J. F. Long, J. H. Albert, J. Kelly, J. Long, J. Long, J. M. Alho, J. Malacic, J. R. N. Stone, J. R. Wilmoth, J. Roy, J. S. Armstrong, J. S. Dyer, J. S. Dyer, J. Simon, K. O. Jörnsten, L. Bulusu, L. Long, L. Long, L. Long, M. Bacharach, M. Batty, M. Batty, M. Bretz, M. M. Kritz, M. Pacini, M. Poulain, M. Poulain, M. Poulain, M. S. Teitelbaum, M. Tribalat, M. V. George, N. Keyfitz, N. Laird, N. Sadiq, NCBS, NCBS, P. Drewe, P. Korcelli, P. M. Jong De, P. McCullagh, P. Rees, P. S. Nair, P. S. Nair, P. T. Harker, P. T. Harker, Ph. Rees, Ph. Rees, R. C. Blattberg, R. Chilton, R. D. Huigen, R. Erf Van der, R. Ferrell, R. Fildes, R. Flowerdew, R. H. Edmundson, R. J. A. Little, R. M. Cooke, R. Pryor, R. Stone, R. T. Appleyard, S. Evans, S. Evans, S. I. Wetrogan, S. K. McNees, S. Koesoebjono, S. Lundström, S. M. MacGill, S. S. Russell, T. C. Lee, T. Cook, T. L. Saaty, T. Straubhaar, United Nations, United Nations, United Nations, United Nations, W. Alonso, W. Bos, W. E. Deming, W. Isard, W. Lutz, Y. M. M. Bishop   +141 more
core   +3 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

The International-Migration Network [PDF]

, 2012
This paper studies international migration from a complex-network perspective. We define the international-migration network (IMN) as the weighted-directed graph where nodes are world countries and links account for the stock of migrants originated in a ...
Fagiolo, Giorgio, Mastrorillo, Marina
core   +2 more sources

A Brief Overview of International Migration Motives and Impacts, with Specific Reference to FDI

, 2017
International migration has become one of the most debated topics in many developed and developing countries. Host countries are concerned about the socioeconomic consequences of international migration, while sending countries—from a developing country ...
Masood Gheasi, P. Nijkamp
semanticscholar   +1 more source