Results 31 to 40 of about 30,589 (310)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Security Aspects of Migrations

Acta Economica et Turistica, 2018
Migrations as an inevitable fact of socioeconomic trends pose a security challenge for migrant countries, transition countries, and the countries where migrants come as to the ultimate destination. They are realized in a large area with a large number of
Vurnek Dragutin, Bengez Andrea, Perkov Matej   +2 more
doaj   +1 more source

On the Economic Geography of International Migration [PDF]

The World Economy, 2015
AbstractWe exploit the bilateral and skill dimensions from recent data sets of international migration to test for the existence of Zipf's and Gibrat's laws in the context of aggregate and high‐skilled international immigration and emigration using graphical, parametric and non‐parametric analysis.
Ozden, Caglar, Parsons, Christopher
openaire   +5 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Lorsque le contrôle des migrations prend le pas sur la sauvegarde de la vie en mer : l’émergence des frontières dans la zone de responsabilité SAR espagnole

Criminologie
Selon les conventions internationales régissant le sauvetage en mer, les frontières maritimes ne doivent pas interférer avec les opérations de sauvetage en mer, la sauvegarde de la vie en mer étant définie comme prioritaire. Pourtant, depuis 2015 et dans
Arnaud Banos, Luna Vives, Camille Martel, Elizabeth Hessek, Kira Williams   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Equilibri e squilibri demografici tra Bacino Mediteraneo, Unione Europea e Mondo Arabo [PDF]

Polis: Revista de Stiinte Politice, 2014
With this research paper the authors do a pertinent analysis of the demographic balances and imbalances and their influence on the international migration phenomenon, in regards to the Mediterranean Basin, the European Union and the Arab world. Starting
Luigi Di COMITE, Simona GIORDANO
doaj  

Internal borders and migration in India* [PDF]

Journal of Economic Geography, 2017
Internal mobility is a critical component of economic growth and development, as it enables the reallocation of labor to more productive opportunities across sectors and regions. Using detailed district-to-district migration data from the 2001 Census of India, the paper highlights the role of state borders as significant impediments to internal ...
Zovanga L. Kone, Maggie Y. Liu, Aaditya Mattoo, Caglar Ozden, Siddharth Sharma, Aaditya Mattoo   +5 more
openaire   +4 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source