Results 51 to 60 of about 2,713,217 (355)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Development of the Extracorporeal Life Support Organization International Adult Extracorporeal Membrane Oxygenation Curriculum [PDF]

, 2023
Jenelle Badulak, Jonah Rubin, Elizabeth A. Moore, Matthew E. Cunningham, Jonathan S. Ilgen, Başak Çoruh, Bishoy Zakhary   +6 more
openalex   +1 more source

Mugabe’s Zimbabwe, 2000–2009: Massive Human Rights Violations and the Failure to Protect [PDF]

, 2010
This article reviews human rights violations in Zimbabwe from 2000 to 2009, under the rule of Robert Mugabe. It argues that these violations, including state-induced famine, illegal mass expulsions, and systemic rape, constituted crimes against humanity.
Howard-Hassmann, Rhoda E.
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Evaluation of Academic Stress Employing Network and Time Series Analysis on EEG Data

Information
Stress management during examinations is an issue perpetually concerning students at all levels of education. This research endeavor focuses not merely on the plethora of factors associated with stress during examinations but rather focuses primarily on ...
Ioannis Konstantinidis, Spyros Avdimiotis, Theodosios Sapounidis   +2 more
doaj   +1 more source

Entrenching the Problem? International Organizations and Their Engagement in Latin America to Address Violence: The Case of the European Union in the Northern Triangle [PDF]

, 2021
Kai Enno Lehmann
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

International Non Governmental Organizations [PDF]

, 2009
This entry considers the history of INGOs in the last two centuries and suggests possible venues for future research.Cette entrée revient sur l'histoire des organisations internationales non gouvernementales au cours des deux derniers siècles et propose ...
Saunier, Pierre-Yves
core   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source