Results 61 to 70 of about 18,167,702 (291)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Ancient Rule Passage Regime Debates in the Turkish Straits: 1841 London Protocol
Turcology Research, 2022 İsmail KÖSE
doaj +1 more source
Entrepreneurial Business and Economics Review, 2018 Objective: To explore in a pilot study which types of trust may be particularly important at different stages of the development of international business relationships.
Łukasz Małys, Krzysztof Fonfara
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
International Organizations and the Promotion of Effective Dispute Resolution [PDF]
, 2019 This second volume of the AIIB Yearbook of International Law examines a series of overarching themes and relationships regarding the role of international organizations in promoting effective dispute resolution.
core +2 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
A Member of the International Code Family Internationall Plumbling Code
, 2006 The I~zt~rr~c~tioPrlr1a~l1 rzbir1Cgo de is kept up to date through thc review of proposed changcs submitted by codc enSo~-cingo fficials,industry rcprescntatives, design professionals and other interested parties.
International Code Council
core
Relationships with Stakeholders in International Research Projects in Poland
Problemy Zarządzania, 2019 The paper investigates the main areas of friction between managers and stakeholders of scientific projects. Five areas are defined and examples of problems are given.
Aleksandra Spik, Michał Mijal
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source