Results 221 to 230 of about 18,489,062 (262)

Continuous Evolution System Based on Toxin–Antitoxin System Combined with Base Deaminase Accelerates the In Vivo Modification of Target Proteins

Advanced Science, EarlyView.
The promoted Escherichia coli‐assisted continuous evolution (PEACE) system operates through a stringent three step genetic circuit: target gene mutation via a deaminase–T7 RNA polymerase (T7 RNAP) fusion, coupling variant function to antitoxin expression, and growth based selection of surviving cells.
Xinyu Zhang, Zhanzhi Liu, Ying Xu, Mingjing Sun, Guangzhen Zhou, Deming Rao, Xiaoqian Chen, Sheng Wang, Zhigang Li, Yan Huang, Jing Wu   +10 more
wiley   +1 more source

Paracetamol: A History of Assumptions, Errors, and Evidence Reversals in Pain Management. [PDF]

Curr Pain Headache Rep
Nicolas J, Leoni MLG, Van Tran Y, Van Phong P, Farì G, Puttini PS, Kaye AD, Varrassi G.   +7 more
europepmc   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Industrializing traditional medical knowledge in China: an integrated governance framework for addressing institutional fragmentation. [PDF]

Front Public Health
Wang Y, Xu K, Hua D.
europepmc   +1 more source

Engineering Morphological Anisotropy to Control the In Vivo Transport Dynamics, Clearance, and Biodistribution of Silica Nanocarriers

Advanced Science, EarlyView.
Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li, Yingjie Yu, Tianchang He, Xiaoyan Fang, Wenhua Yang, Luying Zhou, Hao Fan, Guimei Lin, Daniel Crespy, Katharina Landfester, Junfeng Zhang, Shuai Jiang   +11 more
wiley   +1 more source

Modernizing Pesticide Risk Assessment: Technical Advancements as the Path toward Global Food Security. [PDF]

J Agric Food Chem
Irrig HB, Miller DJ.
europepmc   +1 more source

FAO veterinary vaccine registration: enhancing access to safe and high-quality livestock vaccines for disease control programs and during emergency in countries. [PDF]

One Health Outlook
Cosseddu GM, Qiu Y, Goovaerts D, Metlin A, Blancato D, Maliski S, Tiensin T, Metwally S.   +7 more
europepmc   +1 more source