Results 51 to 60 of about 6,987,249 (299)

Uranus’s complex internal structure

Astronomy & Astrophysics
Context. Uranus’s bulk composition remains unknown. Although there are clear indications that Uranus’s interior is not fully convec-tive, and therefore has a non-adiabatic temperature profile, many interior models continue to assume an adiabatic interior. Aims.
Neuenschwander, Benno A, Müller, Simon, Helled, Ravit   +2 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Single-molecule imaging of UvrA and UvrB recruitment to DNA lesions in living Escherichia coli

Nature Communications, 2016
Nucleotide excision repair is able to identify and remove a wide range of DNA helix distorting lesions from the genome. Here the authors use single molecule imaging of UvrA and UvrB molecules and suggest a two-step ‘scan and recruit’ model for UvrA ...
Mathew Stracy, Marcin Jaciuk, Stephan Uphoff, Achillefs N. Kapanidis, Marcin Nowotny, David J. Sherratt, Pawel Zawadzki   +6 more
doaj   +1 more source

Extensions and Internal Structure

Rocky Mountain Journal of Mathematics, 1993
\(T_ 0\)-extensions \(Y\) of topological spaces \(X\) can be studied by means of suitable traces that \(Y\) leave on \(X\). The author introduces a grid structure on the collection of these traces as a new tool to classify the various kinds of \(T_ 0\)-extensions.
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Spin structure function g_1 at low x: status and plans [PDF]

, 2001
A brief review of measurements and expectations concerning the spin structure function g_1 of the nucleon at low values of the scaling variable x is given.Comment: 4 pages, 3 figures.
Abe, Adeva, Adeva, Adeva, Adeva, B. Badełek, Badełek, Badełek, Bartels, Bartels, Bass, Bass, Blümlein, Burkert, Close, De Roeck, Heimann, Ioffe, Ioffe, Kuti, Kwieciński, Kwieciński, Stratmann, Windmolders   +23 more
core   +3 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Internal structure of black holes [PDF]

Physics Letters B, 1996
We present a number of qualitative arguments which strongly suggest that extremal dyonic black holes in the 4--dimensional low energy, classical field theory limit of toroidally compactified heterotic string theory represent largely degenerate classes of states in the quantum theory.
Larsen, Finn, Wilczek, Frank
openaire   +3 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source