Results 41 to 50 of about 562,035 (264)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Research on Dynamic Energy Management Optimization of Park Integrated Energy System Based on Deep Reinforcement Learning

Energies
Under the background of energy transition, the Integrated Energy System (IES) of the park has become a key carrier for enhancing the consumption capacity of renewable energy due to its multi-energy complementary characteristics.
Xinjian Jiang, Lei Zhang, Fuwang Li, Zhiru Li, Zhijian Ling, Zhenghui Zhao   +5 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Co-creating urban transformation: a stakeholder analysis for Germany’s heat transition

Buildings & Cities
This study analyses a real-world experiment (RWE) on heat transition in the urban context of a city–university partnership in Bochum, Germany, highlighting the theoretical foundations, methodological design and practical challenges of transdisciplinary ...
Pauline Heger, Christoph Bieber, Mennatullah Hendawy, Aryan Shooshtari   +3 more
doaj   +1 more source

Immunogenomic-Based Analysis of Hierarchical Clustering of Diffuse Large Cell Lymphoma

Journal of Immunology Research, 2022
Diffuse large B cell lymphoma (DLBCL) is one of the most usual types of adult lymphoma with heterogeneousness in histological morphology, prognosis, and clinical indications.
Longhao Wang, Wei Yuan, Lifeng Li, Zhibo Shen, Qishun Geng, Yuanyuan Zheng, Jie Zhao   +6 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Enhancing pumping unit diagnosis with similarity splicing data augmentation and wavelet denoising

Scientific Reports
Dynamometer card-based fault diagnosis confronts critical challenges including imbalanced data distributions, noise contamination, and constrained generalization capacity.
Xinlong Tan, Shaohua Wang, Hongqiang Wu, Fei Chen   +3 more
doaj   +1 more source

Is there such a thing as free government data?

Internet Policy Review, 2013
The recently-amended European Public Sector Information (PSI) Directive rests on the assumption that government data is a valuable input for the knowledge economy.
Federico Morando, Raimondo Iemma, Simone Basso   +2 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source