Results 71 to 80 of about 2,899,851 (314)

Is there such a thing as free government data?

open access: yesInternet Policy Review, 2013
The recently-amended European Public Sector Information (PSI) Directive rests on the assumption that government data is a valuable input for the knowledge economy.
Federico Morando   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

High temporal and spatial resolution projected electricity carbon emission factors of China from 2025–2060

open access: yesScientific Data
China’s electric power sector plays a pivotal role in the country’s transition to carbon neutrality. Accurate projections of electricity carbon emission factors with high temporal and spatial resolution are critical for assessing the decarbonization ...
Yaowang Li   +8 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Internet and the Catalan Universities Network. Research report (synthesis document)

open access: yes, 2004
El desenvolupament de les tecnologies de la informació i la comunicació (TIC) durant els darrers quaranta anys del segle XX i la seva incorporació en els diferents àmbits de l'activitat humana ens porten a plantejar-nos, al començament del segle XXI ...
Miralles i Puig, Laia   +1 more
core  

Spatial-Offset Guided and Contrastive Feature Rectification Network for Improved Land Use Classification With Optical and SAR Imagery

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Fusing synthetic aperture radar (SAR) and optical imagery provides more comprehensive information for land use classification. However, significant modality disparities often lead to residual misalignment between the co-registered images, even after ...
Kai Xu   +3 more
doaj   +1 more source

Not The Internet, but This Internet: How Othernets Illuminate Our Feudal Internet

open access: yesAarhus Series on Human Centered Computing, 2015
<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>What is the Internet like, and how do we know? Less tendentiously, how can we make general statements about the Internet without reference to alternatives that help us to understand what the space of network design possibilities might be?
openaire   +3 more sources

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

open access: yesFEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph   +7 more
wiley   +1 more source

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