Results 81 to 90 of about 2,489,122 (261)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Internet/computer addiction among juveniles in Turkey [PDF]

, 2007
Internet and computer addiction has been a popular research area since the 90s. Studies on Internet and computer addiction have usually been conducted in the US, and the investigation of computer and Internet addiction at different countries is an ...
Ozmutlu, H. Cenk, Spink, A., Spink, Amanda H., Özmutlu, H. C., Özmutlu, S., Ozmutlu, Seda   +5 more
core   +1 more source

The relationship between childhood trauma and internet addiction in adolescents with depression: the mediating role of insomnia and alexithymia

BMC Psychiatry
Background The correlation between depressive symptoms and internet addiction in adolescents is strengthened, and childhood trauma is an important predictor of internet addiction.
Xixin Wang, Feng Sun, Feng Geng, Changhao Chen, Jiawei Wang, Xiangwang Wen, Xiangfen Luo, Huanzhong Liu   +7 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Addiction Phenomenology In Substance Use And Non-Substance Use Disorders [PDF]

, 2008
There is growing research evidence and public concern over the burgeoning of disorders which share common features with substance addictions. In order to investigate the presence and role of addiction features in disorders outside of substance addictions,
McLachlan, Andre David
core  

Internet Addiction and Its Relationship with Family Functioning in High School Students

Journal of Holistic Nursing and Midwifery, 2021
Introduction: Family-related factors play an important role in adolescent’s addiction to the Internet. Objective: The aim of this study was to examine the relationship between Internet addiction and family functioning in high school students.
Zahra Harsej, Nasrin Mokhtari Lakeh, Farzaneh Sheikholeslami, Ehsan KazemnezhadLeili   +3 more
doaj  

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

A latent profile transition analysis of internet addiction for rural adolescents and its associations with emotional and interpersonal problems

BMC Psychology
Background Improved internet access has exposed rural adolescents in China to a greater risk of internet addiction. However, existing studies seldom examine the relationship between dynamic changes in internet addiction and psychosocial maladjustment ...
Guogang Xin, Jiaqian Xu, Ling Jiang, Pengyang Li, Qinian Chen, Qing Li, Peiyu Luo, Xiaohua Wang   +7 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source