Results 41 to 50 of about 557,924 (340)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Legitimacy and Expertise in Global Internet Governance [PDF]
, 2015 Over the course of the past decade or so, attention among Internet policymakers and scholars has shifted gradually from substantive design principles to the structure of Internet governance.
Sylvain, Olivier
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Beyond high-tech versus low-tech: A tentative framework for sustainable urban data governance
Big Data & Society, 2023 Technological imaginaries have been increasingly shaping the future perceptions of cities. From artificial intelligence and distributed ledger technology to three-dimensional printing, high-tech artifacts are very often the premises of such imaginaries ...
Vasilis Kostakis +2 more
doaj +1 more source
Social Networks and Democracy: Problems and Dilemmas of Regulating the Digital Ecosystem
Siyasal: Journal of Political Sciences, 2023 The crisis of representative democracy is to a large extent a crisis of disintermediation. Its best known and most studied manifestation is expressed in the weakening of political parties and representative institutions and the link between them and the ...
José-ıgnacio Torreblanca
doaj +1 more source
"Internet universality": Human rights and principles for the internet [PDF]
, 2014 This paper details proposals by UNESCO to manufacture and draft a concept of “Internet Universality” that adopts a human-rights framework as a basis for articulating a set of principles and rights for the Internet.
Peters, Michael A.
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
InformationWith the increasing frequency of digital economic activities on a global scale, internet governance has become a pressing issue. Traditional multilateral approaches to formulating internet governance rules have struggled to address critical challenges ...
Xiaoying Fu, Wenyi Zhang, Zhi Li
doaj +1 more source
Understanding Media Control in the Digital Age
Media and Communication, 2021 Media control comprises multifaceted and amorphous phenomena, combining a variety of forms, tools, and practices. Today media control takes place in a sphere where national politics meet global technology, resulting in practices that bear features of ...
Olga Dovbysh, Esther Somfalvy
doaj +1 more source
The Distributed Secretariat: Making the Internet Governance Forum Work [PDF]
, 2006 International policy discussions are heavily dependent on the substantive preparatory activities of a Secretariat. IGP has prepared a paper outlining a new way for the Internet Governance Forum to meet the need for a substantive Secretariat.
John Mathiason
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