Results 41 to 50 of about 1,617,840 (334)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Personal networking function of the Internet [PDF]
Sociologija, 2009 The aim of the paper is to understand the role of Internet in creating new forms of sociability in the modern society. In the first part the history of social studies of Internet is reviewed, and the conclusion put forward that the anti-social role of ...
Petrović Dalibor
doaj +1 more source
The Future of “Fair and Balanced”: The Fairness Doctrine, Net Neutrality, and the Internet [PDF]
, 2009 In recent months, different groups--pundits, politicians, and even an FCC Commissioner--have discussed resurrecting the now-defunct Fairness Doctrine and applying it to Internet communication. This iBrief responds to the novel application of the Doctrine
Leonhardt, Sasha
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Internet authentication based on personal history - a feasibility test [PDF]
, 2005 On the Internet, there is an uneasy tension between the security and usability of authentication mechanisms. An easy three-part classification is: 'something you know' (e.g. password); 'something you hold' (e.g.
Connor, R., Dunlop, M.D., Nosseir, A.
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Asian internet histories: an introduction [PDF]
, 2021 Gerard Goggin, Haiqing Yu, Kwang-Suk Lee
openalex +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Méta-Internet : les surfblogs sont-ils de mauvais genre ?
Itinéraires, 2010 Surfblogs are a network metaform of a particular kind: they reach beyond what is said to belong to the proper genre of the blog to reflect user information processing at the network scale.
Camille Paloque-Berges
doaj +1 more source