Results 111 to 120 of about 95,461 (252)

Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model

Advanced Science, EarlyView.
Nano‐pulling is a magnetic nanoparticle‐based technology for guiding and promoting the axon growth of induced pluripotent stem cell‐derived dopaminergic neurospheres in vitro or neural progenitors transplanted in the brain tissue. Fine control of axon guidance is essential for reconstructing neural networks and restoring functional connectivity in the ...
Sara De Vincentiis, Elena Capitanini, Karen Kira, Claudia Dell'Amico, Jun Takahashi, Marco Onorati, Fabian Raudzus, Vittoria Raffa   +7 more
wiley   +1 more source

Ti3C2Tx MXene‐Zirconium Diboride Based Ultra‐High Temperature Ceramics

Advanced Science, EarlyView.
This study demonstrates the effectiveness of Ti3C2Tx MXenes as additives in ultra‐high‐temperature ceramics (ZrB₂), enhancing densification, reducing oxygen content, and improving mechanical properties. Through surfactant‐free electrostatic self‐assembly and spark plasma sintering, MXenes enabled the formation of a core–shell microstructure, resulting ...
Srinivasa Kartik Nemani, Nicola Gilli, Steven Goldy, Ankit Kumar, Yooran Im, Austin J. Vorhees, Brian C. Wyatt, Nithin Chandran BS, Nikhilesh Chawla, Garritt J. Tucker, Laura Silvestroni, Babak Anasori   +11 more
wiley   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

The SlDOF9‐SlSWEET17 Module: a Switch for Controlling Sugar Distribution Between Nematode Induced Galls and Roots in Tomato

Advanced Science, EarlyView.
Root‐knot nematode (RKN) disease seriously affects the yield and quality of vegetable crops. SlDOF9‐SlSWEET17 model helps plants resist RKN infection during early stage by switching off the sugar transport capacity of other SlSWEET proteins that are hijacked by RKNs.
Xiaoyun Wang, Zhimei Wang, Xinyue Tang, Jiamei Qin, Xiaoxuan Zhou, Lixia Gu, Huihui Bian, Lulu Sun, Huang Huang, Rui Yang, Jianli Wang, Shaohui Wang, Shuangchen Chen, Zhongren Yang, Wenchao Zhao   +14 more
wiley   +1 more source

Surface Rolling Active Magnetic Emulsions

Advanced Science, EarlyView.
This study presents synergistic combination of materials to augment the life‐like chemotactic abilities of oil droplets towards microrobotics applications. Magnetically actuated autonomous oil droplets possess on‐demand switchable locomotion modalities with augmented navigation in complex confined spaces and can perform cargo transportation.
Muhammad Turab Ali Khan, Gaurav Gardi, Ugur Bozuyuk, Metin Sitti   +3 more
wiley   +1 more source

Hydrogen‐Producing Catalysts Based on Ferredoxin Scaffolds

Advanced Science, EarlyView.
Selected plant‐type ferredoxins that lack their natural [2Fe‐2S] clusters functionally bind a hydrogenase active site cofactor and act as hydrogenases themselves. In combination with photosystem I, the light‐dependent H₂ evolution almost matches the H₂ production rates of the natural system.
Yiting She, Vera Engelbrecht, Jacek Kozuch, Ulf‐Peter Apfel, Sven T. Stripp, Anja Hemschemeier, Thomas Happe   +6 more
wiley   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

A Touch Enabled Hemodynamic and Metabolic Monitor

Advanced Science, EarlyView.
This work presents a touch‐based hybrid platform for simultaneous monitoring of vital signs and sweat metabolites. With a simple tri‐finger touch of 4–6 min, users can concurrently get to know their glucose, uric acid, cortisol levels from fingertip sweat, along with blood pressure and heart rate.
Omeed Djassemi, Tamoghna Saha, Ponnusamy Nandhakumar, Muhammad Inam Khan, Hannah Fishman, Sara Earney, Chochanon Moonla, Yuchen Xu, Henry Thai, Sofia Morales‐Fermin, Gyeongho Kim, Rhea Park, Beya Acot, Oscar Wu, Cannon Wurster, An‐Yi Chang, Christopher Cheung, Julia Silberman, Shichao Ding, Joseph Wang   +19 more
wiley   +1 more source

Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling

Advanced Science, EarlyView.
The premature aging‐related progerin leads to defective nuclear morphology and is associated with disrupted molecular coupling between the extranuclear cytoskeleton and lamin‐associated nuclear envelope. It is discovered that progerin expression reduces nuclear tension, forms nuclear wrinkling, and enhances chromatin dynamics, thereby regulating ...
Ji‐Eun Park, Juhyeon Jo, Kun Xu, Sun‐Ah Lee, Seong‐Beom Han, YigJi Lee, Won‐Ki Cho, Bo Li, Soo Hyun Kim, Dong‐Hwee Kim   +9 more
wiley   +1 more source

Mn3SnN‐Based Antiferromagnetic Tunnel Junction with Giant Tunneling Magnetoresistance and Multi‐States: Design and Theoretical Validation

Advanced Science, EarlyView.
A non‐collinear Mn3SnN/SrTiO3/Mn3SnN (001) AFMTJ is proposed with a theoretical TMR exceeding 1500%, enabled by optimal momentum (k)‐space matching between Mn3SnN's spin‐polarized Fermi surface (pk||${p}_{{\bm{k}}_{\mathbf{|}\mathbf{|}}}$) and the low‐decay‐rate (κk||${\kappa}_{{\bm{k}}_{\mathbf{|}\mathbf{|}}}$) of the SrTiO3 barrier.
Shiqi Liu, Tingwei Chen, Baochun Wu, Haodong Fan, Yingmei Zhu, Sheng Bi, Yuntian Liu, Yinuo Shi, Wenbiao Zhang, Mengxi Wang, Qiang Li, Jie Yang, Jing Lu, Tiejun Zhou, Bo Liu   +14 more
wiley   +1 more source