Results 281 to 290 of about 1,818,152 (349)

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

AI alignment is all your need for future drug discovery. [PDF]

Front Artif Intell
Li C.
europepmc   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

LBNet: an optimized lightweight CNN for mammographic breast cancer classification with XAI-based interpretability. [PDF]

Sci Rep
Ahmmed J, Ahmed F, Kabir MA, Ahad MT, Jadoon MA, Rehman AU, Bermak A.   +6 more
europepmc   +1 more source

Pathway-guided architectures for interpretable AI in biological research. [PDF]

Comput Struct Biotechnol J
Zhou Q, Madala NS, Huang C.
europepmc   +1 more source

Research on key indicators for diagnosis and prediction of rheumatoid arthritis based on GBDT+LR embedded feature selection model. [PDF]

Front Immunol
Chen J, Zhang Q, Huang Z, Qu C.
europepmc   +1 more source

LASO(f): A Unified Constitutional Framework for Deterministic AI Action and Interpretive Governance

Edward Meyman
openalex   +1 more source

Bridging computational power and environmental challenges: a perspective on neural network predictive models for environmental engineering. [PDF]

Front Artif Intell
Facuy J, Arcos-Jacome D.
europepmc   +1 more source