Results 151 to 160 of about 3,708,057 (315)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Legal Interpretation of Tax Law: China
, 2014 This report reviews existing law on the legal interpretation, and depicts the tax system in China with a special emphasis on the legislation of tax law and the historical background of the devolution of legislative powers.
Qiu, DD
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Interpretation Model of Urban Space Coherence
, 2011 The paper presents our efforts to establish a model for urban space interpretation (IMUSC Interpretation Model of Urban Spatial Coherence), intended as a pragmatic instrument for recognizing elements and phenomena that affect actual use of urban spaces ...
T.Strojan Zupancic +2 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Room for Interpretation : Musical Performance Interacting with Room Acoustics
, 2015 The research project ‘Room for Interpretation: Musical Performance Interacting with Room Acoustics’, funded by the Swedish Research Council, is conducted at the Piteå School of Music, Luleå University of Technology. The project engages researchers within
Berg, Jan, +4 more
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
"Ich verstehe es nicht": the necessity of integrating professional interpretation into the German healthcare system. [PDF]
Int J Equity HealthLo HY, Copes S, Hoe C.
europepmc +1 more source
WJ III clinical use and interpretation : scientist-practitioner perspectives /
, 2003 WJ III Clinical Use and Interpretation presents a wide variety of clinical applications of the WJ III from leading experts. Each chapter will provide the reader with insights into patterns of cluster and test scores from both the WJ III Tests of ...
Schrank, Fredrick A.(Fredrick Allen) +1 more
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