Results 221 to 230 of about 8,422,143 (298)

Methodological Reflections from Engaging Five Culturally and Linguistically Unique U.S. Muslim Populations. [PDF]

Healthcare (Basel)
Ali AM, Salihu EY, Abdelwahab S, Shiyanbola OO, Vivian E, Chewning B.   +5 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Letter to the editor regarding to "association of acute kidney injury stages with in-hospital and long-term mortality in older adults with hip fractures". [PDF]

Ann Med
Liu S.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The challenges of implementing hybrid baselines for the interpretation of longitudinal behavioral data from individuals. [PDF]

NPJ Digit Med
Just SA, Tedeschi E, Holsbø E, Mikalsen KØ, Bongo LA, Homan P, Elvevåg B.   +6 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic. [PDF]

Neurology
Groot C, Calandri IL, Bader I, Bocancea DI, de Bruin H, Carrigan M, Collij LE, Duits FH, Kamps S, de Koning LA, Lemstra AW, Mastenbroek SE, Rikken RM, van Tol BGJ, Vermeiren MR, Wesseling A, Xia Y, Teunissen CE, van de Giessen E, Barkhof F, Jonkman LE, de Boer C, Rozemuller AJ, Leeuwis AE, van der Vlies AE, Tijms BM, van der Flier WM, Pijnenburg YAL, Coomans EM, Ossenkoppele R.   +29 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Cutaneous squamous cell carcinomas secondary to hydroxyurea: a case report. [PDF]

An Bras Dermatol
Guerra Galvão Santos R, Martins Lobo Jardim M, Guerra Guedes L, de Lima Pereira IC.   +3 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source