Results 111 to 120 of about 309,034 (308)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
From Self-Interpreters to Normalization by Evaluation [PDF]
, 2009 We characterize normalization by evaluation as the composition of a self-interpreter with a self-reducer using a special representation scheme, in the sense of Mogensen (1992).
Boespflug, Mathieu
core +3 more sources
A Proof Strategy Language and Proof Script Generation for Isabelle/HOL
, 2017 We introduce a language, PSL, designed to capture high level proof strategies in Isabelle/HOL. Given a strategy and a proof obligation, PSL's runtime system generates and combines various tactics to explore a large search space with low memory usage ...
A Bundy +10 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
A Low-Overhead Script Language for Tiny Networked Embedded Systems [PDF]
, 2006 With sensor networks starting to get mainstream acceptance, programmability is of increasing importance. Customers and field engineers will need to reprogram existing deployments and software developers will need to test and debug software in network ...
Dunkels, Adam
core +3 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Secondary Traumatic Stress in Interpreters for Refugees: Why Training and Supervision Matter
Psychiatry InternationalInterpreters who translate for refugees are regularly confronted with traumatic content. Listening regularly to and translating potentially traumatizing stories make interpreters vulnerable to secondary traumatization.
Gerhard Hapfelmeier +4 more
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Intégrer un interprète dans les consultations de médecine familiale : une analyse de discours assistée par ordinateur [PDF]
Çédille: Revista de Estudios Franceses, 2014 We set up a research to explore representations of working with interpreters among family physicians in Quebec City. Focus-groups (FGs) with third year medical students (6, N= 22), residents (4, N= 29) and senior physicians (5, N= 47) were conducted.
Yvan Leanza +2 more
doaj