Results 111 to 120 of about 873,606 (299)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Determining and Interpreting the Key Financial Indicators in an Audiovisual Organization

open access: yesCECCAR Business Review
The audiovisual sector represents a field of activity that has experienced extraordinary dynamics over the past decades, reflecting itself in increasing individual diversity, as well as increasing competition within the field.
Bogdan Cosmin GOMOI
doaj   +1 more source

“Maybe I Say Something, I Understand a Bit”: On the (In)Accessibility of Translation

open access: yesSocial Inclusion
Working with interpreters is common in qualitative social research. It can even be necessary when researchers address the perspective of people with whom they do not share a lingua franca.
Natalie Bella
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

InterpNET: A Curated Repository of Sign Language & Interpreting Resources

open access: yesJournal of Open Humanities Data
InterpNET is a curated digital repository of open-source, web-based resources related to sign language and interpretation. The dataset was assembled through a systematic online search and verification process designed to identify, review, and confirm the
Kierstin Muroski
doaj   +1 more source

An Interpretation Of Rawls’ “Kantian Interpretation”

open access: yesCon-textos Kantianos: International Journal of Philosophy, 2015
Calling Kant a liberal philosopher requires important qualifications. Much like his theoretical philosophy, his political transcendentalism was and remains a great enterprise of navigating between the extremes of liberalism and conservatism, of balancing the “empirical” and the “pure” in human society, as well as in human mind.
openaire   +3 more sources

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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