Results 171 to 180 of about 873,606 (299)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Setting up a multilingual & inclusive survey

Resuscitation Plus
Sinem Bilican, Antoon Cox, Birgitte Schoenmakers, Marc Sabbe, Heidi Salaets   +4 more
doaj   +1 more source

Interpreting the Efficacy of Liposomal Bupivacaine in Fascial Plane Blocks for Elderly Patients: A Methodological Reappraisal [Letter]. [PDF]

Drug Des Devel Ther
Gai H, Hou Y, Yu Y.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Interpreting race-neutral lung function equations: methodological considerations from an Australian study. [PDF]

Intern Med J
Ali M.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Correction to: Dynamic time warping analysis of accelerometry data: a tool for interpreting fine-scale movement patterns during fish angling events. [PDF]

Conserv Physiol
europepmc   +1 more source

Clarifying the Assessment of Emergence Agitation and Postoperative Recovery in Young Children Receiving Ciprofol or Propofol for Dental Surgery [Letter]. [PDF]

Drug Des Devel Ther
Zhao Q.
europepmc   +1 more source

Affects in On-Demand Mobile App Interpreting in Public Service Settings: Interpreters’ Experiences

This article investigates the affects public service interpreters experience whenthey work remotely with the help of technology, that is, when they interpretusing mobile interpreting apps.
Viljanmaa, Anu
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source