Results 61 to 70 of about 76,934 (306)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Designing a Maintenance Management Model based on Interpretive Structural Modeling [PDF]
مدیریت بهره وری, 2019 The worldwide development of Maintenance Management Models (MMM) underscores the need of various organizations to take into account contextual and organizational differences and to design a model that is congruent with their context-based requirements ...
mohammad Hossian karimi Govareshaki +2 more
doaj
Managing digital coordination of design: emerging hybrid practices in an institutionalized project setting [PDF]
, 2011 What happens when digital coordination practices are introduced into the institutionalized setting of an engineering project? This question is addressed through an interpretive study that examines how a shared digital model becomes used in the late ...
Anumba C. J. +16 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Building Information Modelling [BIM] for energy efficiency in housing refurbishments [PDF]
, 2015 Building Information modelling offers potential process and delivery improvements throughout the lifecycle of built assets. However, there is limited research in the use of BIM for energy efficiency in housing refurbishments.
Comlay, Julie, Tzortzopoulos, Patricia
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Work-Family Conflict and Job Satisfaction: the Mediating Role of Person-Organization Fit Study on Employees of the BRI Aceh Region [PDF]
, 2016 The objective of this research is to analyze the influence of person–organizationfit (P-O fit) on work–family conflict (WFC) and job satisfaction (JS) relationships atBank Rakyat Indonesia, Aceh Regional in Banda Aceh.
Ibrahim, M. (Mahdani), Yusra, Y. (Yusra)
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Linguistics and some aspects of its underlying dynamics [PDF]
, 2015 In recent years, central components of a new approach to linguistics, the Minimalist Program (MP) have come closer to physics. Features of the Minimalist Program, such as the unconstrained nature of recursive Merge, the operation of the Labeling ...
Piattelli-Palmarini, Massimo +1 more
core +3 more sources
C. S. Peirce and Intersemiotic Translation [PDF]
, 2015 Intersemiotic translation (IT) was defined by Roman Jakobson (The Translation Studies Reader, Routledge, London, p. 114, 2000) as “transmutation of signs”—“an interpretation of verbal signs by means of signs of nonverbal sign systems.” Despite its ...
Aguiar, Daniella, Queiroz, Joao
core +1 more source