Results 81 to 90 of about 76,934 (306)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Four facets of a process modeling facilitator [PDF]
, 2011 Business process modeling as a practice and research field has received great attention in recent years. However, while related artifacts such as models, tools or grammars have substantially matured, comparatively little is known about the activities ...
Hjalmarsson, Anders +3 more
core +3 more sources
A Combinatorial Parametric Engineering Model for Solid Freeform Fabrication [PDF]
, 2004 Fabricated parts are often represented as compact connected smooth 3-manifolds with boundary, where the boundaries consist of compact smooth 2-manifolds. This class of mathematical structures includes topological spaces with enclosed voids and tunnels.
Boudreaux, J.C.
core +1 more source
Modelling of the bioeconomy system using interpretive structural modelling
, 2019 Due to European and global resource efficiency efforts, the bioeconomy research and the search for new bioresource valorisation alternatives has become topical. Bioeconomy directly concerns such major sectors of the economy as agriculture, forestry, fishery, as well as other indirect bioeconomy sectors.
Kubule, A., Indzere, Z., Muizniece, I.
openaire +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Implementing lean manufacturing system: ISM approach
Journal of Industrial Engineering and Management, 2013 Purpose: Lean Manufacturing System has emerged as an important area of research in Indian context. The requirement of Lean Manufacturing has increased due to defects in products (semi finished and finished) and subsequent increase in cost.
Naveen Kumar +3 more
doaj +1 more source
Intersectionality as a Regulative Ideal [PDF]
, 2019 Appeals to intersectionality serve to remind us that social categories like race and gender cannot be adequately understood independently from each other. But what, exactly, is the intersectional thesis a thesis about?
Gasdaglis, Katherine, Madva, Alex
core
Determining the psychometric properties of the Enhancing Decision-making Assessment in Midwifery (EDAM) measure in a cross cultural context [PDF]
, 2016 © 2016 Jefford et al. Background: The ability to act on and justify clinical decisions as autonomous accountable midwifery practitioners, is encompassed within many international regulatory frameworks, yet decision-making within midwifery is poorly ...
Jefford, Elaine +2 more
core +3 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
A Cognitive Model of an Epistemic Community: Mapping the Dynamics of Shallow Lake Ecosystems [PDF]
, 2005 We used fuzzy cognitive mapping (FCM) to develop a generic shallow lake ecosystem model by augmenting the individual cognitive maps drawn by 8 scientists working in the area of shallow lake ecology.
A. Chao +54 more
core +2 more sources