Results 191 to 200 of about 77,843 (262)

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

Advanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo, Rohit Verma, Sydney C. Nagy, Mausam Kalita, Samuel Aubert, Josué Ballesteros‐Álvarez, Pedro Machado Almeida, Hannes Vogel, Israt S. Alam, Michael Lim, Michelle L. James   +10 more
wiley   +1 more source

Incidental Extrinsic Cardiac Compression by a Pericardial Mass: Echocardiographic and CT Correlation. [PDF]

US Cardiol
Ciuciureanu CM, Iorgoveanu C, Milutinovic S, Singh K, Kramer J.   +4 more
europepmc   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Making sense of commercial genomic reports in oncology: a structured approach from clinical practice. [PDF]

Front Oncol
Gharaybeh A, Al-Sukhun S.
europepmc   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Cardiac implantable electronic devices remote monitoring service at National University Heart Centre, Singapore. [PDF]

Indian Pacing Electrophysiol J
Tan ES, Lee JY, Yeo WT, Kojodjojo P.
europepmc   +1 more source

Stop comparing spells: a defense of mechanistic reasoning in quantitative medicine. [PDF]

Front Digit Health
Mangalam M, Kiyono K.
europepmc   +1 more source

Conformational reprogramming of c-Myc <i>via</i> intracellular cyclisation. [PDF]

RSC Chem Biol
Johnson RA, Mason JM.
europepmc   +1 more source

Electrocardiographic Identification and Correction of Left Ventricular Pacing Latency. [PDF]

J Cardiovasc Echogr
Muralidharan TR, Nivetha DR, Sanjith S, Naveen MV, Shriram AA, Logavengatesh KV, Veerasamy RS, Aravind CS, Babu K.   +8 more
europepmc   +1 more source