Results 251 to 260 of about 27,854 (318)

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

Technological Evolution and Research Trends of Intelligent Question-Answering Systems in Healthcare. [PDF]

Healthcare (Basel)
Lei B, Yin P.
europepmc   +1 more source

Reconstructing Coherent Functional Landscape From Multi‐Modal Multi‐Slice Spatial Transcriptomics by a Variational Spatial Gaussian Process

Advanced Science, EarlyView.
This study introduces stVGP, a variational spatial Gaussian process framework for multi‐modal, multi‐slice spatial transcriptomics. By integrating histological and genomic data through hybrid alignment and attention‐based fusion, stVGP reconstructs coherent 3D functional landscapes.
Zedong Wang, Bowen Fu, Chuanchao Zhang, Xiaoping Liu   +3 more
wiley   +1 more source

BHLHE40 Orchestrates Effector Tissue‐Resident Memory CD8+ T Cells and Limits Long‐Term Survival of Kidney Graft

Advanced Science, EarlyView.
An effector subset of TRM, defined as CD49a+PD1hi CD8+ TRM, represents a BHLHE40‐orchestrated resident immune component that, rather than circulating cells, plays as a major contributor to allograft rejection. ABSTRACT Tissue‐resident memory T cells (TRM), which function against tumors, infections, and non‐self antigens in organ transplantation ...
Junbo Li, Bo Yang, Tianhui Pan, Xi Zhou, Zhibo Ma, Du Tang, Bowen Xie, Jing Liu, Zhishui Chen, Peixiang Lan   +9 more
wiley   +1 more source

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, EarlyView.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

A Generative Expert-Narrated Simplification Model for Enhancing Health Literacy Among the Older Population. [PDF]

Bioengineering (Basel)
Abdusalomov A, Umirzakova S, Mirzakhalilov S, Kutlimuratov A, Nasimov R, Temirov Z, Jeong W, Choi H, Whangbo TK.   +8 more
europepmc   +1 more source

A multistream attention based neural network for visual speech recognition and sign language understanding. [PDF]

Sci Rep
Talaat FM, Hassan BM.
europepmc   +1 more source

Context-Dependent Learning of Linguistic Disjunction. [PDF]

J Child Lang
Jasbi M, Jaggi A, Clark EV, Frank MC.
europepmc   +1 more source

Validation of the Language ENvironment Analysis (LENA) Automated Speech Processing Algorithm Labels for Adult and Child Segments in a Sample of Families From India. [PDF]

J Speech Lang Hear Res
Meera SS, Swaminathan D, Venkata Murali SR, Raju R, Srikar M, Shyam Sundar S, Amudhan S, Cristia A, Pawar R, Rao A, Vasuki PP, Volme S, Mysore A.   +12 more
europepmc   +1 more source