Results 181 to 190 of about 260,111 (309)

A Retrospective Analysis of Nearly 3,000,000 Non-COVID-19 Mid- and High-Priority Ambulance Activations Before and During COVID-19: A National Study from Saudi Arabia. [PDF]

Healthcare (Basel)
Alqahtani SA, Alshammari TM, Alshamrani AM, Alshabaani TL, Esmael TM, Mahmood AA, Alamri AA, Alshamrani AA, Alshaye NH, Alamri AS, Aldossary SR, Alsofayan YM, Alhajjaj FS, Alkhaldi JM, Alrawashdeh AA.   +14 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The rebound-initiating viral reservoir (RIVR) in SIV/SHIV infection is dominated by plasma virus sequences present at the time of ART initiation. [PDF]

J Virol
Pinkevych M, Docken SS, Wu Y, Schlub T, Harper JL, Viox EG, Samer S, Kulpa D, Betts MR, Keele BF, Paiardini M, Bar KJ, Cromer D, Davenport MP.   +13 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Closing the "Missing Middle" in Advanced HIV Disease Care for Adolescents in Sub-Saharan Africa: Early Identification, Integrated Care, and Continuity After Discharge. [PDF]

HIV AIDS (Auckl)
Manirafasha EN.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Congenital Bronchial Atresia Mimicking Pulmonary Sequestration in the Lower Lobe: A Case Report. [PDF]

Respirol Case Rep
Mitsumata S, Midorikawa K, Wakamatsu K, Kaneda S, Futamata T, Iwanaka T, Ueda Y, Miyahara S, Masuda Y, Nakashima H, Sato T.   +10 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Bird, Interrupted

Scientific American, 2018
openaire   +2 more sources

Nutritional status and weight trajectories during radiotherapy in patients with cancer: a retrospective cohort study. [PDF]

Front Nutr
Liu T, Wu S.
europepmc   +1 more source